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Table 1 B vitamin status, tHcy, plasma creatinine and lifestyle data according to sex and age group

From: Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine

 

Women, age (years) groups, n [%]

Men, age (years) groups, n [%]

<35

154 [39.7]

≥35 to <60

176 [45.4]

≥60

58 [14.9]

<35

134 [37.3]

≥35 to <60

169 [47.1]

≥60

56 [15.6]

EGRACa, b

1.46 (1.41, 1.50)

1.34 (1.31, 1.38)***

1.33 (1.26, 1.39)**

1.41 (1.36, 1.45)

1.36 (1.33, 1.39)

1.32 (1.25, 1.40)*

Marginally deficientc

32.9 (24.8, 39.3)

36.3 (29.0, 43.1)

36.1 (23.6, 47.4)

38.2 (29.1, 45.2)

45.3 (37.7, 52.5)

44.6 (31.0, 56.7)‡

Deficientc

49.7 (40.7, 56.2)

30.2 (23.3, 36.7)‡‡‡

26.2 (14.9, 36.7)§§§

38.2 (29.1, 45.2)

30.2 (23.2, 36.9)

19.6 (9.1, 29.5)‡‡‡,§§§

EASTACc, d

1.69 (1.65, 1.72)

1.69 (1.65, 1.72)

1.64 (1.58, 1.70)

1.66 (1.63, 1.70)

1.64 (1.61, 1.68)

1.59 (1.53, 1.65)

Deficientc

60.9 (52.1, 67.4)

56.2 (48.3, 62.8)

42.4 (28.1, 52.5)‡

58.5 (48.2, 64.6)

51.5 (43.4, 58.3)

48.4 (34.4, 60.3)

PF (nmol/L)e

9.4 (8.8, 10.2)

13.8 (12.7, 14.9)***

16.9 (14.5, 19.6)***,†††

8.6 (7.9, 9.4)

11.6 (10.8, 12.5)***

14.96 (12.83, 17.44)***,†††

B12 (pmol/L)e

319 (300, 340)

377 (358, 376)***

348 (315, 386)

350 (331, 371)

350 (332, 368)

318 (286, 353)

tHcy (µmol/L)f

8.4 (8.0, 8.7)

8.51 (8.23, 8.80)

11.0 (10.1, 11.9)***,†††

10.0 (9.6, 10.5)

10.3 (10.0, 10.7)

11.65 (11.03, 12.30)***,†††

Creatininef (µmol/L)e

65.8 (64.5, 67.1)

63.9 (62.7, 65.2)

66.9 (64.5, 69.3)

81.9 (80.2, 83.7)

81.6 (79.6, 83.6)

83.8 (80.2, 87.4)

BMIa (kg/m2)

23.4 (22.8, 24.0)

27.8 (27.0, 28.7)

31.3 (29.9, 32.8)**

25.0 (24.4, 25.7)

29.0 (28.4, 29.6)

28.8 (27.7, 30.0)

Smokersc

49.7 (41.9, 57.5)

22.9 (16.7, 28.9)‡‡‡

1.6 (0.4, 4.8)‡‡‡,§§§

45.7 (37.5, 54.0)

37.6 (30.4, 44.8)

24.6 (13.4, 35.7)‡‡‡

Alcohola (g/day)

8.2 (1.9, 18.3)

7.2 (2.2, 12.1)

6.6 (0.5, 12.8)

80.6 (48.1, 113.1)

126.5 (79.7, 173.4)***

84.2 (29.3, 139.2)††

  1. PF plasma folate, tHcy total fasting plasma homocysteine
  2. ANOVA: * p < 0.05; ** p < 0.01; *** p < 0.001 versus <35 years; ††  p < 0.01; †††  p < 0.001 versus ≥35 to <60 years. χ2: ‡  p < 0.05; ‡‡‡  p < 0.001 versus <35 years; §§§  p < 0.001 versus ≥35 to <60 years
  3. aArithmetic mean, b riboflavin status determined by the functional erythrocyte glutathione reductase activation coefficient assay (EGRAC), c % (95 % CI), d vitamin B6 status determined by the functional erythrocyte aspartate aminotransferase activation coefficient assay (EASTAC), e geometric mean, f geometric mean adjusted for study centre (95 % CI)
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