Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation

Table 1 Characteristics of the subjects

	Pre-n-3 PUFA supplementation	Post-n-3 PUFA supplementation	Δ	p value
Sex (men/women)	97/113
Age (years)	30.8 ± 8.7
Weight (kg)	81.3 ± 13.9	81.6 ± 14.2		0.82
BMI (kg/m²)	27.8 ± 3.7	27.9 ± 3.8		0.81
Plasma desaturase activity
D5D (20:4n-6/20:3n-6)	3.57 ± 1.15	4.34 ± 1.25	25.71 ± 28.83 (n = 210)	<0.0001
D6D (20:3n-6/18:2n-6)	0.17 ± 0.05	0.14 ± 0.04	−17.68 ± 18.15 (n = 210)	<0.0001
Plasma elongase activity
ELOVL2 (22:4n-6/20:4n-6)	0.0318 ± 0.0064	0.0193 ± 0.0093	−39.52 ± 27.89 (n = 209)	<0.0001
Omega-6 (% of total FAs)
Linoleic acid, C18:2n-6, LA	19.71 ± 2.08	17.69 ± 2.22	−9.85 ± 10.76	<0.0001
Arachidonic acid, C20:4n-6, AA	11.05 ± 1.74	9.74 ± 1.44	−11.20 ± 9.99	<0.0001
Omega-3 (% of total FAs)
Alpha-linolenic acid, C18:3n-3, ALA	0.18 ± 0.15	0.14 ± 0.12	−31.44 ± 50.44	0.0002
Eicosapentaenoic acid, C20:5n-3, EPA	1.12 ± 0.52	4.10 ± 1.28	331.11 ± 214.74	<0.0001
Docosahexaenoic acid, C22:6n-3, DHA	3.53 ± 0.77	5.03 ± 0.86	46.31 ± 27.46	<0.0001
Omega-6 (μg/ml)
Linoleic acid C18:2n-6, LA	227.26 ± 44.46	199.16 ± 45.38	−11.63 ± 15.82	<0.0001
Arachidonic acid, C20:4n-6, AA	128.14 ± 32.77	109.63 ± 27.03	−13.04 ± 14.26	<0.0001
Omega-3 (μg/ml)
Alpha-linolenic acid, C18:3n-3, ALA	2.22 ± 1.89	1.72 ± 1.52	−32.08 ± 51.42	<0.0001
Eicosapentaenoic acid, C20:5n-3, EPA	12.92 ± 6.41	46.15 ± 16.99	328.79 ± 227.51	<0.0001
Docosahexaenoic acid, C22:6n-3, DHA	40.97 ± 12.54	57.04 ± 16.05	43.55 ± 33.50	<0.0001

Measurements made prior to- and after a 6-week n-3 FA supplementation; values are mean ± SD
The rate of change (Δ) expressed as the relative variation of plasma FAs as a percentage (%) or absolute quantities (μg/ml) between the pre- and post-n-3 PUFA period. Differences between the pre- and post-n-3 PUFA supplementation were tested using a pairwise Student’s t test

ISSN: 1865-3499