Table 6 δ-5 Desaturase indexes (AA:DGLA) after a 6-week n-3 PUFA supplementation according to genotype for each SNPs of the FADS gene cluster (n = 208)
Pre-n-3 PUFA D5D activitya | Post-n-3 PUFA D5D activitya | p values | |||||||
|---|---|---|---|---|---|---|---|---|---|
11 | 12 or 12 + 22 | 22 | 11 | 12 or 12 + 22 | 22 | SNPs | Suppl. | Interaction | |
FADS1 | |||||||||
rs174546 | 4.132 ± 1.179 | 3.166 ± 0.807 | 2.376 ± 0.572 | 4.787 ± 1.138 | 4.091 ± 1.123 | 3.086 ± 0.739 | <0.0001 | <0.0001 | 0.20 |
FADS2 | |||||||||
rs498793 | 3.457 ± 1.413 | 3.567 ± 1.076 | 3.816 ± 0.815 | 4.317 ± 1.291 | 4.383 ± 1.178 | 4.304 ± 1.391 | 0.09 | <0.0001 | 0.63 |
rs174579 | 3.860 ± 1.222 | 3.130 ± 0.886 | – | 4.575 ± 1.282 | 3.981 ± 1.108 | – | <0.0001 | <0.0001 | 0.32 |
rs174611 | 2.934 ± 0.760 | 3.209 ± 0.949 | 3.919 ± 1.226 | 4.544 ± 1.152 | 4.167 ± 1.385 | 3.735 ± 0.666 | <0.0001 | <0.0001 | 0.08 |
rs174616 | 3.272 ± 1.203 | 3.563 ± 1.162 | 3.904 ± 0.019 | 4.485 ± 1.098 | 4.469 ± 1.298 | 3.948 ± 1.129 | 0.04 | <0.0001 | 0.09 |
FADS3 | |||||||||
rs174456 | 3.706 ± 0.993 | 3.377 ± 1.106 | 3.767 ± 1.951 | 4.468 ± 1.258 | 4.187 ± 1.154 | 4.436 ± 1.592 | 0.07 | <0.0001 | 0.86 |
Intergenic regions | |||||||||
rs174627 | 3.732 ± 1.200 | 3.080 ± 0.847 | – | 4.444 ± 1.251 | 4.017 ± 1.194 | – | 0.0006 | <0.0001 | 0.14 |
rs12807005 | 3.569 ± 1.150 | 3.700 ± 1.547 | – | 4.360 ± 1.257 | 3.609 ± 0.488 | – | 0.56 | 0.02 | 0.07 |
rs174448 | 3.859 ± 0.990 | 3.526 ± 1.268 | 2.800 ± 0.717 | 4.539 ± 1.113 | 4.327 ± 1.372 | 3.681 ± 0.792 | 0.001 | <0.0001 | 0.59 |