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Table 7 δ-6 Desaturase indexes (DGLA:LA) after a 6-week n-3 PUFA supplementation according to genotype for each SNPs of the FADS gene cluster

From: Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation

 

Pre-n-3 PUFA D6D activitya

Post-n-3 PUFA D6D activitya

p values

11

12 or 12 + 22

22

11

12 or 12 + 22

22

SNPs

Suppl.

Interaction

FADS1

 rs174546

0.160 ± 0.043

0.179 ± 0.046

0.180 ± 0.054

0.132 ± 0.038

0.143 ± 0.042

0.142 ± 0.041

0.02

<0.0001

0.23

FADS2

 rs498793

0.172 ± 0.049

0.169 ± 0.042

0.169 ± 0.054

0.138 ± 0.044

0.134 ± 0.037

0.145 ± 0.045

0.64

<0.0001

0.51

 rs174579

0.166 ± 0.044

0.176 ± 0.048

0.135 ± 0.041

0.141 ± 0.040

0.04

<0.0001

0.23

 rs174611

0.165 ± 0.050

0.179 ± 0.048

0.163 ± 0.043

0.137 ± 0.039

0.139 ± 0.043

0.132 ± 0.035

0.23

<0.0001

0.01

 rs174616

0.178 ± 0.045

0.168 ± 0.048

0.164 ± 0.043

0.139 ± 0.036

0.132 ± 0.041

0.147 ± 0.043

0.34

<0.0001

0.11

FADS3

 rs174456

0.166 ± 0.042

0.172 ± 0.051

0.177 ± 0.044

0.136 ± 0.039

0.137 ± 0.041

0.143 ± 0.048

0.73

<0.0001

0.57

Intergenic regions

 rs174627

0.167 ± 0.045

0.178 ± 0.048

0.137 ± 0.041

0.137 ± 0.037

0.29

<0.0001

0.02

 rs12807005

0.170 ± 0.046

0.177 ± 0.035

0.137 ± 0.041

0.163 ± 0.033

0.29

<0.0001

0.20

 rs174448

0.162 ± 0.041

0.172 ± 0.049

0.184 ± 0.047

0.135 ± 0.037

0.139 ± 0.044

0.140 ± 0.037

0.30

<0.0001

0.09

  1. Repeated MIXED procedure implemented in S.A.S statistical software v. 9.3 adjusted for age, sex and BMI
  2. aValues are mean ± SD