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Table 8 Index of elongase activity (22:4n-6/20:4n-6) after a 6-week n-3 PUFA supplementation according to genotype for each SNPs of the ELOVL gene family

From: Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation

 

Pre-n-3 PUFA index of elongase activitya

Post-n-3 PUFA index of elongase activitya

p values

11

12 or 12 + 22

22

11

12 or 12 + 22

22

SNPs

Suppl.

Interaction

ELOVL2

 rs13204015

3.06E−2±0.53E−2

3.20E−2±0.65E−2

2.09E−2±0.64E−2

1.92E−2±0.96E−2

0.89

<0.0001

0.15

 rs12195587

3.23E−2±0.62E−2

3.08E−2±0.69E−2

1.88E−2±0.96E−2

2.04E−2±0.86E−2

0.98

0.0005

0.02

 rs4532436

3.01E−2±0.49E−2

3.18E−2−2±0.66E−2

3.40E−2±0.68E−2

1.89E−2±0.75E−2

1.97E−2±0.96E−2

1.86E−2±1.04E−2

0.52

<0.0001

0.05

 rs3734397

3.20E−2±0.67E−2

3.22E−2±0.56E−2

2.87E−2±0.65E−2

1.93E−2±0.99E−2

2.00E−2±0.81E−2

1.51E−2±0.95E−2

0.11

<0.0001

0.85

 rs2281591

3.20E−2±0.62E−2

3.11E−2±0.65E−2

3.64E−2±0.52E−2

2.05E−2±0.89E−2

1.76E−2±0.95E−2

2.22E−2±0.99E−2

0.01

<0.0001

0.22

 rs3798710

3.14E−2±0.61E−2

3.29E−2±0.69E−2

1.89E−2±0.90E−2

2.01E−2±1.00E−2

0.06

<0.0001

0.83

ELOVL5

 rs209492

3.17E−2−2±0.62E−2

3.24E−2±0.69E−2

1.91E−2±0.92E−2

1.99E−2±0.98E−2

0.45

<0.0001

0.94

 rs2073040

3.18E−2±0.65E−2

3.19E−2±0.61E−2

3.22E−2±0.72E−2

1.83E−2±1.05E−2

1.97E−2±0.87E−2

2.07E−2±0.75E−2

0.63

<0.0001

0.43

 rs2294852

3.15E−2±0.73E−2

3.22E−2±0.60E−2

3.16E−2±0.61E−2

1.84E−2±1.01E−2

1.95E−2±0.96E−2

2.00E−2±0.78E−2

0.83

<0.0001

0.62

 rs9370194

3.21E−2±0.67E−2

3.17E−2±0.61E−2

1.87E−2±1.07E−2

1.98E−2±0.79E−2

0.98

<0.0001

0.20

  1. Repeated MIXED procedure implemented in S.A.S statistical software v. 9.3 adjusted for age, sex, and BMI
  2. aValues are mean ± SD