Fig. 1
The mRNA expression levels of genes related to fatty acid metabolism (a) and glycerolipid synthesis and lipolysis (b) in PBMCs of hamsters fed with a STD or a high-fat diet for 30 days receiving a daily oral dose of GSPE (25 mg per kg body weight) (the STD-GSPE and HFD-GSPE groups) or the vehicle (the STD and HFD groups) for the last 15 days. The gene expression results represent the mean ± SEM (n = 7–8) of the ratios of specific mRNA levels to β-actin, expressed as a percentage versus the STD group which was set to 100 %. D the effect of the type of diet, T the effect of GSPE treatment, DxT, the interaction of the type of diet and GSPE treatment (two-way ANOVA, p < 0.05). abMean values with unlike letters were significantly different among groups (one-way ANOVA and LSD post hoc test, p < 0.05). *Versus the STD group (Student’s t test, p < 0.05). Acadvl, acyl-coa dehydrogenase, very long chain; Acc, acetyl-coenzyme a carboxylase; Atgl, adipose triglyceride lipase; Cpt1β, carnitine palmitoyltransferase beta; Dgat2, diacylglycerol acyltransferase-2; Fabppm: fatty acid-binding protein plasma membrane; Fas, fatty acid synthase; Gyk: glycerol kinase; Gpat, glycerol-3-phosphate acyltransferase; Hsl, hormone-sensitive lipase; Lpl: lipoprotein lipase; Pparα, peroxisome proliferator-activated receptor alpha; Pparγ, peroxisome proliferator-activated receptor gamma; Scd1, stearoyl-coa desaturase-1; Srebp1, sterol regulatory element-binding protein 1; Ucp2, uncoupling protein 2 (mitochondrial, proton carrier)