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Fig. 3 | Genes & Nutrition

Fig. 3

From: The intake of a high-fat diet and grape seed procyanidins induces gene expression changes in peripheral blood mononuclear cells of hamsters: capturing alterations in lipid and cholesterol metabolisms

Fig. 3

The mRNA expression levels of genes related to cholesterol (a) and lipid metabolism (b) in the liver of hamsters fed with a STD or a high-fat diet for 30 days receiving a daily oral dose of GSPE (25 mg per kg body weight) (the STD-GSPE and HFD-GSPE groups) or the vehicle (the STD and HFD groups) for the last 15 days. The gene expression results represent the mean ± SEM (n = 7–8) of the ratios of specific mRNA levels to β-actin, expressed as a percentage versus the STD group which was set to 100 %. D the effect of the type of diet (two-way ANOVA, p < 0.05). abMean values with unlike letters were significantly different among groups (one-way ANOVA and LSD post hoc test, p < 0.05). Abcg1, ATP-binding cassette, sub-family G (WHITE), member 1; Acat2, Acat2 acetyl-CoA acetyltransferase 2; Atgl, adipose triglyceride lipase; Cpt1α, carnitine palmitoyltransferase alpha; Dgat2, diacylglycerol acyltransferase-2; Fas, fatty acid synthase; Gpat, glycerol-3-phosphate acyltransferase; Hmgcr, 3-hydroxy-3-methylglutaryl-CoA reductase; Ldlr, low-density lipoprotein receptor; Pparα, peroxisome proliferator-activated receptor alpha; Srb1, scavenger receptor class B, member 1; Srebp1, sterol regulatory element-binding protein 1; Srebp2, sterol regulatory element-binding protein 2

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