TNF-α gene expression is increased following zinc supplementation in type 2 diabetes mellitus

Genes & Nutrition

Table 2 Bivariate Pearson’s correlations between fold changes of cytokines, zinc transporters and metallothionein when analysed in all participants (n = 38^a) and according to whether participants received (zinc, n = 20) or did not receive (control, n = 18) zinc supplements for 12 weeks

	ZnT1	ZnT5	ZnT6	ZnT7	ZnT8 ^b	Zip1	Zip3	Zip7	Zip10	MT-1A	MT-2A
IL-1β
All	0.28	0.28	0.33*	0.44**	−0.03	0.42**	0.38*	0.24	0.14	0.19	0.36
Zinc	0.33	0.49*	0.27	0.57**	−0.23	0.51*	0.31	0.27	0.24	0.10	0.37
Control	0.31	0.24	0.42	0.29	0.04	0.35	0.70**	0.33	−0.06	0.38	0.32
IL-6
All	0.07	0.21	0.29	0.43**	0.05	0.06	0.38*	0.22	0.42**	0.51**	0.14
Zinc	−0.08	−0.13	0.09	0.32	−0.13	0.10	0.46*	0.31	0.43	0.59**	0.24
Control	0.29	0.61**	0.49*	0.54*	0.32	0.04	0.41	0.18	0.39	0.40	−0.01
TNF-α
All	0.31	0.39*	0.45**	0.56**	0.10	0.52**	0.34*	0.44**	0.33*	0.33*	0.60**
Zinc	0.31	0.44	0.41	0.60**	0.11	0.64**	0.49*	0.48*	0.40	0.28	0.65**
Control	0.42	0.55*	0.49*	0.57*	−0.12	0.46	0.36	0.54*	0.22	0.43	0.55*

* P < 0.05; ** P < 0.01
^aMissing data for expression of zinc transporters and metallothionein for two participants
^b ZnT8 mRNA expression was detected in seven participants supplemented with zinc and nine participants not supplemented with zinc

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