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Table 2 Bivariate Pearson’s correlations between fold changes of cytokines, zinc transporters and metallothionein when analysed in all participants (n = 38a) and according to whether participants received (zinc, n = 20) or did not receive (control, n = 18) zinc supplements for 12 weeks

From: TNF-α gene expression is increased following zinc supplementation in type 2 diabetes mellitus

  ZnT1 ZnT5 ZnT6 ZnT7 ZnT8 b Zip1 Zip3 Zip7 Zip10 MT-1A MT-2A
IL-
All 0.28 0.28 0.33* 0.44** −0.03 0.42** 0.38* 0.24 0.14 0.19 0.36
Zinc 0.33 0.49* 0.27 0.57** −0.23 0.51* 0.31 0.27 0.24 0.10 0.37
Control 0.31 0.24 0.42 0.29 0.04 0.35 0.70** 0.33 −0.06 0.38 0.32
IL-6
All 0.07 0.21 0.29 0.43** 0.05 0.06 0.38* 0.22 0.42** 0.51** 0.14
Zinc −0.08 −0.13 0.09 0.32 −0.13 0.10 0.46* 0.31 0.43 0.59** 0.24
Control 0.29 0.61** 0.49* 0.54* 0.32 0.04 0.41 0.18 0.39 0.40 −0.01
TNF-α
All 0.31 0.39* 0.45** 0.56** 0.10 0.52** 0.34* 0.44** 0.33* 0.33* 0.60**
Zinc 0.31 0.44 0.41 0.60** 0.11 0.64** 0.49* 0.48* 0.40 0.28 0.65**
Control 0.42 0.55* 0.49* 0.57* −0.12 0.46 0.36 0.54* 0.22 0.43 0.55*
  1. P < 0.05; ** P < 0.01
  2. aMissing data for expression of zinc transporters and metallothionein for two participants
  3. b ZnT8 mRNA expression was detected in seven participants supplemented with zinc and nine participants not supplemented with zinc