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Table 2 Processes of phenotypic flexibility modulated by OLTT

From: Phenotypic flexibility as a measure of health: the optimal nutritional stress response test

Organ system Process Direction (↑, ↓, –) Disturbed
Gut Incretin production (GIP) ↑ (GLP-1) NASH, MetS
Gut-mediated inflammation Obesity, T2DM, IGT
Adipose tissue Lipolysis Obesity, MetS, NASH
Adipokine production NASH, obesity
Systemic stress Insulin sensitivity  
Oxidative stress NASH, obesity
Nitrosative stress T2DM
Inflammation MetS
Metabolic flexibility MetS, obesity
Liver Lipoprotein production NASH, T2DM, obesity, IGT
Hepatic injury control NASH
Vasculature Blood pressure regulation Obesity
Adhesion T2DM
Vascular flexibility T2DM
Pancreas Insulin secretion a MetS, obesity
  1. MetS metabolic syndrome, T2DM type 2 diabetes mellitus, IFG impaired fasting glucose, IGT impaired glucose tolerance, NASH non-alcoholic steatohepatitis
  2. aDependent on carbohydrates in OLTT