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Table 1 Conceptual flow of the manuscript

From: The genomics of micronutrient requirements

Step

Concepts

1

Health status is the ability of an individual to adapt and self-manage

2

Micronutrient status and phenotype have an impact on health status

3

Micronutrient nutritional phenotype is determined by differences in genetic-environment interactions that cannot be understood using the one-gene–one-polypeptide approach

4

Micronutrient nutritional phenotype can be characterized by an integrated set of quantitative genetic, proteomic, metabolomics, functional, dietary intake, and behavioral data characterized with extensive metadata

5

Integration of data is possible using computational system modeling

6

N-of-1 trials are studied where each participant is in his/her own control and will metabolically respond to a (micro)nutrient intervention challenge

7

The systematic comparison of phenotypic responses of individuals exposed to different diets using omics approaches may be used to validate and to better understand the role of the diet and micronutrient needs in the etiology of health