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Table 3 Serum levels of TNF-α, IL-1β, and IL-6 in control, CP, and CP rats pretreated with 18β-GA

From: 18β-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARγ and Nrf2 upregulation

Parameter

Control

CP

CP + 25 mg GA

CP + 50 mg GA

TNF-α (pg/mL)

34.17 ± 5.02

124.33 ± 14.32***

62.08 ± 8.79###

40.19 ± 3.99###$

IL-1β (pg/mL)

26.75 ± 4.36

89.43 ± 13.76***

39.34 ± 7.76###

32.11 ± 6.27###

IL-6 (pg/mL)

39.29 ± 6.58

93.69 ± 7.81***

65.92 ± 8.94###

47.01 ± 7.07###

  1. Data are M ± SD (N = 6)
  2. TNF-α tumor necrosis factor alpha, IL interleukin, CP cyclophosphamide, GA glycyrrhetinic acid, SD standard deviation, vs versus
  3. *** P < 0.001 versus control, ### P < 0.001 versus CP, and $ P < 0.05 versus CP + 25 mg GA group
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Genes & Nutrition

ISSN: 1865-3499

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