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Table 3 Multiple regression models using changes in all or ‘clusters’ of zinc transporters identified by principal component analysis to predict the change in MT-2A gene expression over the study period

From: Zinc-induced upregulation of metallothionein (MT)-2A is predicted by gene expression of zinc transporters in healthy adults

Dependent variable

Factors

r 2

Overall

P value

Univariate component

Standardised coefficient (β) ± standard error

Univariate

P value

Δ MT-2A

Δ All ZnTs and ZIPsa

0.542

0.029

ZIP1

0.89 ± 0.26

0.003

Δ Cluster 1b

0.477

0.003

ZIP1

0.77 ± 0.22

0.002

Δ Cluster 2c

0.073

NS

–

–

–

  1. Based on complete data available for analysis (n = 33)
  2. a ZnT1, ZnT5, ZnT6, ZnT7, ZIP1, ZIP3, ZIP7, ZIP8, ZIP10, and ZIP14
  3. b ZIP1, ZIP3, ZIP7, ZIP10, and ZIP14
  4. c ZnT1, ZnT5, ZnT6, ZnT7, and ZIP8