Fig. 2

Glucose homeostasis and plasma FGF21 in F1 and N2 NZO backcross wild type (wt) and UCP1 transgenic (tg) mice fed a high-fat diet from weaning until week 23 (F1-generation) or week 20 (N2-generation). Blood glucose levels and plasma insulin during glucose tolerance test performed in week 20 in F1 generation (a, b; n = 7–8) and week 16 in N2 generation (c, d; n = 8–10). e Highest individual random blood glucose levels achieved during HFD feeding period (n = 10–22). f FGF21 plasma levels of N2 wt and tg mice at 20 weeks of age (n = 8). Data are mean ± SE. *p < 0.05; **p < 0.01; ***p < 0.001 compared to wt