Table 1 Body composition and plasma parameters of F1 and N2 NZO backcross wild type (wt) and UCP1 transgenic (tg) mice fed a high-fat diet from weaning

Body weight (g)

56.0 ± 1.6 (20)

38.5 ± 1.2*** (21)

66.4 ± 3.9 (12)

55.1 ± 4.1 (10)

Lean mass (g)

31.8 ± 0.4 (20)

24.5 ± 0.3*** (21)

31.1 ± 0.5 (12)

28.1 ± 0.9** (10)

Lean mass (%)

56.9 ± 1.3 (20)

64.5 ± 1.7** (21)

48.5 ± 2.7 (12)

53.1 ± 3.4 (10)

Fat mass (g)

24.9 ± 1.5 (20)

14.3 ± 1.2*** (21)

35.3 ± 3.7 (12)

27.1 ± 3.5 (10)

Fat mass (%)

43.3 ± 1.3 (20)

35.7 ± 1.7** (21)

51.6 ± 2.7 (12)

47.0 ± 3.4 (10)

Body length (cm)

11.6 ± 0.05 (24)

11.1 ± 0.05*** (26)

11.7 ± 0.2 (12)

11.6 ± 0.1 (10)

BMI (kg/m²)

4.18 ± 0.10 (19)

3.12 ± 0.08*** (21)

4.92 ± 0.21 (12)

4.22 ± 0.24* (10)

Liver weight (%)

4.03 ± 0.12 (20)

4.32 ± 0.11 (21)

4.07 ± 0.14 (12)

4.26 ± 0.22 (10)

Diabetes prevalence

15 % (22)

0 %* (20)

42 % (12)

0 %* (10)

Random blood glucose (mg/dl)

204.4 ± 30 (22)

116.6 ± 3** (20)

286 ± 35 (12)

172 ± 17** (10)

Random insulin (ng/ml)

21.9 ± 3.8 (11)

7.5 ± 1.9*** (20)

32.0 ± 11.9 (10)

21.7 ± 9.0 (8)

Fasting blood glucose (mg/dl)

89.2 ± 9.9 (9)

60.8 ± 3.3** (11)

122 ± 9.2 (10)

88 ± 9.0** (8)

Fasting insulin (ng/ml)

2.08 ± 0.18 (9)

1.16 ± 0.11*** (11)

2.34 ± 0.62 (10)

1.61 ± 0.40 (8)

HOMA index

11.7 ± 2.1 (9)

4.4 ± 0.6** (11)

20.5 ± 6.9 (10)

9.5 ± 3.1 (8)

Plasma TG (µg/ml)

830 ± 105 (25)

938 ± 85 (26)

586 ± 92 (12)

764 ± 92 (10)

Plasma FFA (mM)

1.21 ± 0.21 (25)

0.64 ± 0.09* (26)

0.93 ± 0.15 (12)

1.03 ± 0.23 (10)

Plasma IGF1 (ng/ml)

n.d.

n.d.

564 ± 32 (8)

509 ± 26 (8)