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Table 4 Liver and renal function test markers at post treatment days 15 and 30

From: Comparative anti-inflammatory and lipid-normalizing effects of metformin and omega-3 fatty acids through modulation of transcription factors in diabetic rats

  Control (n = 6) STZ (n = 6) Metformin (n = 6) Flax oil (n = 6) Fish oil (n = 6)
Liver function test markers
 Post treatment day 15
  SGOT (U/ml) 104.10 ± 3.97 123.46 ± 6.98 162.11 ± 20.38 133.84 ± 13.60 116.79 ± 8.20
  SGPT (U/ml) 113.08 ± 5.56 167.50 ± 15.28* 199.83 ± 20.03 202.16 ± 7.52 220.08 ± 12.47
  ALP (KA Unit) 28.15 ± 4.06 113.46 ± 33.45* 103.88 ± 15.53 91.22 ± 11.19 98.98 ± 4.34
  Bilirubin (mg/dl) 0.08 ± 0.18 0.11 ± 0.02 0.12 ± 0.04 0.09 ± 0.01 0.10 ± 0.01
 Post treatment day 30
  SGOT (U/ml) 113.71 ± 9.81 124.00 ± 8.45 134.48 ± 9.27 120.38 ± 10.69 136.15 ± 6.41
  SGPT (U/ml) 87.50 ± 9.10 134.80 ± 24.83 160.33 ± 32.84 150.00 ± 34.53 198.50 ± 22.43
  ALP (KA Unit) 15.78 ± 1.59 75.34 ± 6.49** 69.63 ± 9.41 53.80 ± 5.78 58.29 ± 10.88
  Bilirubin (mg/dl) 0.08 ± 0.01 0.11 ± 0.03 0.14 ± 0.01 0.06 ± 0.02 0.06 ± 0.02
Renal function test markers
 Post treatment day 15
  Creatinine (mg/dl) 1.44 ± 0.27 2.38 ± 0.23 1.86 ± 0.17 1.49 ± 0.27 1.50 ± 0.28
  Urea (mg/dl) 38.37 ± 3.37 56.11 ± 3.57** 56.88 ± 4.24 46.95 ± 2.26 46.33 ± 3.12
  Albumin (g/dl) 2.19 ± 0.15 1.83 ± 0.23 1.61 ± 0.26 1.88 ± 0.11 2.15 ± 0.19
  Total protein (g/dl) 4.00 ± 0.18 3.68 ± 0.29 3.86 ± 0.68 3.80 ± 0.25 4.07 ± 0.20
 Post treatment day 30
  Creatinine (mg/dl) 1.28 ± 0.15 1.69 ± 0.30 1.61 ± 0.33 1.33 ± 0.10 1.22 ± 0.34
  Urea (mg/dl) 40.52 ± 4.50 49.38 ± 3.48 50.88 ± 2.29 60.57 ± 2.35 51.22 ± 4.80
  Albumin (g/dl) 2.09 ± 0.14 1.70 ± 0.17 1.54 ± 0.10 1.68 ± 0.11 1.80 ± 0.20
  Total protein (g/dl) 3.71 ± 0.09 3.42 ± 0.81 3.08 ± 0.19 3.31 ± 0.14 3.23 ± 0.12
  1. Data are presented as mean ± SE
  2. SGOT serum glutamic oxaloacetic transaminase, SGPT serum glutamic pyruvic transaminase, ALP alkaline phosphatase
  3. *p < 0.05, **p < 0.01 for comparison between the control and STZ group