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Table 4 Liver and renal function test markers at post treatment days 15 and 30

From: Comparative anti-inflammatory and lipid-normalizing effects of metformin and omega-3 fatty acids through modulation of transcription factors in diabetic rats

 

Control (n = 6)

STZ (n = 6)

Metformin (n = 6)

Flax oil (n = 6)

Fish oil (n = 6)

Liver function test markers

 Post treatment day 15

  SGOT (U/ml)

104.10 ± 3.97

123.46 ± 6.98

162.11 ± 20.38

133.84 ± 13.60

116.79 ± 8.20

  SGPT (U/ml)

113.08 ± 5.56

167.50 ± 15.28*

199.83 ± 20.03

202.16 ± 7.52

220.08 ± 12.47

  ALP (KA Unit)

28.15 ± 4.06

113.46 ± 33.45*

103.88 ± 15.53

91.22 ± 11.19

98.98 ± 4.34

  Bilirubin (mg/dl)

0.08 ± 0.18

0.11 ± 0.02

0.12 ± 0.04

0.09 ± 0.01

0.10 ± 0.01

 Post treatment day 30

  SGOT (U/ml)

113.71 ± 9.81

124.00 ± 8.45

134.48 ± 9.27

120.38 ± 10.69

136.15 ± 6.41

  SGPT (U/ml)

87.50 ± 9.10

134.80 ± 24.83

160.33 ± 32.84

150.00 ± 34.53

198.50 ± 22.43

  ALP (KA Unit)

15.78 ± 1.59

75.34 ± 6.49**

69.63 ± 9.41

53.80 ± 5.78

58.29 ± 10.88

  Bilirubin (mg/dl)

0.08 ± 0.01

0.11 ± 0.03

0.14 ± 0.01

0.06 ± 0.02

0.06 ± 0.02

Renal function test markers

 Post treatment day 15

  Creatinine (mg/dl)

1.44 ± 0.27

2.38 ± 0.23

1.86 ± 0.17

1.49 ± 0.27

1.50 ± 0.28

  Urea (mg/dl)

38.37 ± 3.37

56.11 ± 3.57**

56.88 ± 4.24

46.95 ± 2.26

46.33 ± 3.12

  Albumin (g/dl)

2.19 ± 0.15

1.83 ± 0.23

1.61 ± 0.26

1.88 ± 0.11

2.15 ± 0.19

  Total protein (g/dl)

4.00 ± 0.18

3.68 ± 0.29

3.86 ± 0.68

3.80 ± 0.25

4.07 ± 0.20

 Post treatment day 30

  Creatinine (mg/dl)

1.28 ± 0.15

1.69 ± 0.30

1.61 ± 0.33

1.33 ± 0.10

1.22 ± 0.34

  Urea (mg/dl)

40.52 ± 4.50

49.38 ± 3.48

50.88 ± 2.29

60.57 ± 2.35

51.22 ± 4.80

  Albumin (g/dl)

2.09 ± 0.14

1.70 ± 0.17

1.54 ± 0.10

1.68 ± 0.11

1.80 ± 0.20

  Total protein (g/dl)

3.71 ± 0.09

3.42 ± 0.81

3.08 ± 0.19

3.31 ± 0.14

3.23 ± 0.12

  1. Data are presented as mean ± SE
  2. SGOT serum glutamic oxaloacetic transaminase, SGPT serum glutamic pyruvic transaminase, ALP alkaline phosphatase
  3. *p < 0.05, **p < 0.01 for comparison between the control and STZ group