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Table 1 Metabolic parameters at the end of experimental periods

From: Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats

 

Control (n = 10)

Curcumin (n = 10)

THC (n = 10)

Positive control (n = 10)

Normal control (n = 10)

Body weight at fourth week (g)

347 ± 32a

332 ± 30a

337 ± 29a

301 ± 22b

346 ± 31a

Body weight at seventh week (g)

332 ± 34b

328 ± 33b

329 ± 35b

297 ± 26c

367 ± 36a

Food intake at fourth week (g)

14.8 ± 1.7

14.0 ± 1.5

13.6 ± 2.0

13.1 ± 1.4

14.7 ± 1.8

Food intake at seventh week (g)

13.3 ± 1.6b

14.3 ± 1.9ab

14.0 ± 1.8ab

13.1 ± 1.7b

15.4 ± 1.7a

Average intake of supplements (mg/day)

–

57.4 ± 6.5

55.6 ± 6.1

–

–

Peri-uterine fat (g)

7.9 ± 1.1a

6.1 ± 0.7b

6.7 ± 0.8b

4.9 ± 0.9c

8.4 ± 0.9a

Retroperitoneum fat (g)

11.7 ± 2.0a

9.9 ± 1.1b

7.4 ± 1.0c

5.8 ± 0.5d

12.3 ± 1.8a

Uterine weight (g)

0.17 ± 0.06b

0.22 ± 0.07b

0.20 ± 0.05b

0.51 ± 0.08a

0.18 ± 0.05b

Serum 17β-estradiol levels (pg/ml)

1.6 ± 0.6b

1.8 ± 0.5b

1.9 ± 0.5b

7.5 ± 1.1a

1.7 ± 0.6b

Serum triglyceride (mg/dL)

85.9 ± 5.3a

71.9 ± 6.4b

70.4 ± 7.4b

68.3 ± 6.6b

84.3 ± 5.5a

Serum glucose (mg/dL)

103 ± 8a

98 ± 7a

100 ± 8a

88 ± 10b

102 ± 7a

Serum insulin (ng/mL)

1.49 ± 0.17a

1.21 ± 0.14b

1.26 ± 0.17b

1.19 ± 0.11b

1.43 ± 0.15a

HOMA-IR

8.5 ± 0.9a

6.6 ± 0.8b

6.9 ± 0.9b

5.8 ± 0.6c

8.1 ± 0.8a

  1. Ovariectomized (OVX) rats were provided with a 45 % fat diet containing (1) 0.4 % curcumin, (2) 0.4 % tetrahydrocurcumin (THC), (3) 30 μg/kg body weight 17β-estradiol + 0.4 % dextrose (positive control), (4) 0.4 % dextrose (control), or (5) 0.4 % dextrose (normal control for osteoarthritis). At the beginning of the fifth week, an articular injection of monoiodoacetate into the right knee was performed on all OVX groups except the normal-control group and the assigned diets were provided for additional 3 weeks. Rats in the normal-control group had an articular injection of saline in the right knee. Values are mean ± SD
  2. a, b, cValues on the same row with different superscripts were significantly different among groups by the Tukey test at P < 0.05