Fig. 2

Effect of ND compared to CD on gene expression changes after a 2hOGTT. The effect of the healthy ND compared to the CD on TLR4 mRNA expression (a), IL18 mRNA expression (b), CD36 mRNA expression (c), and PPARD mRNA expression (d) presented as fold change (2^−ΔCt of 2hOGTT/2^−ΔCt of 0hOGTT) in the healthy ND group (n = 42–49) and in the CD group (n = 32–40) after intervention. Fold changes (2^−∆ΔCt) are normalized for the reference gene TBP and fasting values (0hOGTT). The box plots show the 2^−∆ΔCt values at the end of the intervention. Box plots show the medians with 25th and 75th percentiles. Whiskers express the 1.5 × interquartile range. The number sign is a q value of 0.042. The q values indicate the effect of the ND compared to the CD on gene expression changes after a 2hOGTT. The effect of the independent variable study group is adjusted for fold change at baseline (log2 transformed) and study centers. A q value <0.05 (FDR < 5 %) was considered significant