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Table 3 Interaction between variants in WNT-associated genes and quintiles of fiber intake on type 2 diabetes incidence

From: Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes

    Genotype HRb, c, d, e 95 % CI P b, c, d, e
  Alleles Risk allele XX XRa RR    
TCF7L2 rs7903146 C/T T 13,475 9414 1720 1.20c 1.05–1.36 0.006
Fiber       0.96d 0.93–0.998 0.037
TCF7L2 rs7903146 × Fiber       1.04e 1.003–1.09 0.034
TCF7L2 rs12255372 G/T T 13,517 9689 1785 1.06 0.93–1.21 0.36
Fiber       0.95 0.91–0.98 0.003
TCF7L2 rs12255372 × Fiber       1.06 1.02–1.10 0.005
HHEX rs1111875 A/G G 4329 12,518 8816 0.99 0.88–1.11 0.83
Fiber       0.95 0.90–1.00 0.05
HHEX rs1111875 × Fiber       1.03 0.99–1.07 0.14
HNF1A rs7957197 A/T T 1067 8549 16,401 1.15 0.99–1.34 0.06
Fiber       1.00 0.92–1.08 0.92
HNF1A rs7957197 × Fiber       0.99 0.95–1.04 0.75
NOTCH2 rs10923931 G/T T 20,612 4372 228 1.24 1.02–1.51 0.035
Fiber       1.00 0.97–1.03 0.97
NOTCH2 rs10923931 × Fiber       0.93 0.87–0.99 0.017
TLE4 rs13292136 C/T C 186 3928 21,962 0.99 0.81–1.23 0.96
Fiber       0.97 0.86–1.10 0.66
TLE4 rs13292136 × Fiber       1.01 0.94–1.07 0.88
ZBED3 rs4457053 A/G G 13,455 9362 1642 1.22 1.06–1.39 0.004
Fiber       1.02 0.98–1.05 0.38
ZBED3 rs4457053 × Fiber       0.94 0.90–0.98 0.002
PPARG rs1801282 G/C C 548 6263 19,038 1.18 0.99–1.40 0.06
Fiber       1.01 0.92–1.12 0.77
PPARG rs1801282 × Fiber       0.98 0.93–1.04 0.52
PPARG rs13081389 A/G A 165 3256 21,423 0.97 0.77–1.21 0.77
Fiber       0.93 0.81–1.07 0.30
PPARG rs13081389 × Fiber       1.03 0.96–1.10 0.46
  1. HR hazard ratio
  2. aX designates the non-risk allele and R designates the risk allele
  3. bAdjusted for age, sex, BMI, total energy intake, dietary assessment method, season, leisure-time physical activity, smoking, alcohol intake, and education
  4. cMain effect per risk allele from the multivariable model including the interaction term
  5. dMain effect per quintile of fiber intake from the multivariable model including the interaction term
  6. eInteraction effect