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Table 4 HR of incident type 2 diabetes by genotype and quintiles of fiber intake

From: Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes

   Genotype    
  XX XRa RR HR per R allele P trend b P interaction c
TCF7L2 rs7903146       
  Q1 1.16 (0.98–1.39) 1.58 (1.32–1.89) 1.56 (1.14–2.15) 1.24 (1.09–1.40) 0.001 0.034
  Q2 1.13 (0.95–1.35) 1.52 (1.27–1.82) 1.92 (1.43–2.60) 1.26 (1.11–1.42) 0.0002  
  Q3 1.15 (0.97–1.37) 1.62 (1.36–1.93) 2.10 (1.60–2.77) 1.37 (1.22–1.55) 1 × 10−7  
  Q4 1.02 (0.85–1.22) 1.35 (1.12–1.62) 1.93 (1.48–2.58) 1.31 (1.15–1.49) 5 × 10−5  
  Q5 1 (ref) 1.70 (1.42–2.03) 2.00 (1.49–2.70) 1.47 (1.30–1.66) 2 × 10−9  
  HR per Q 0.97 (0.93–1.01) 0.99 (0.95–1.03) 1.05 (0.95–1.15)    
  P trend c 0.19 0.64 0.37    
TCF7L2 rs12255372       
  Q1 1.22 (1.03–1.45) 1.44 (1.20–1.73) 1.27 (0.90–1.78) 1.08 (0.95–1.22) 0.26 0.005
  Q2 1.16 (0.98–1.38) 1.32 (1.10–1.58) 1.74 (1.31–2.32) 1.16 (1.02–1.31) 0.02  
  Q3 1.07 (0.90–1.28) 1.53 (1.29–1.82) 1.89 (1.44–2.47) 1.36 (1.21–1.53) 3 × 10−7  
  Q4 1.02 (0.86–1.22) 1.27 (1.05–1.52) 1.68 (1.25–2.26) 1.23 (1.08–1.40) 0.002  
  Q5 1 (ref) 1.41 (1.18–1.68) 1.99 (1.48–2.67) 1.40 (1.23–1.59) 4 × 10−7  
  HR per Q 0.96 (0.92–1.00) 0.98 (0.94–1.02) 1.05 (0.96–1.16)    
  P trend 0.060 0.37 0.28    
NOTCH2 rs10923931        
  Q1 1.00 (0.87–1.14) 1.14 (0.92–1.42) 1.66 (0.86–3.23) 1.12 (0.93–1.34) 0.24 0.017
  Q2 1.00 (0.88–1.14) 1.04 (0.85–1.28) 0.76 (0.28–2.04) 1.06 (0.88–1.28) 0.51  
  Q3 1.03 (0.91–1.18) 1.10 (0.90–1.35) 1.05 (0.47–2.34) 1.08 (0.90–1.30) 0.41  
  Q4 0.97 (0.85–1.11) 0.70 (0.55–0.90) 0.75 (0.28–2.00) 0.75 (0.60–0.95) 0.015  
  Q5 1 (ref) 1.00 (0.80–1.25) 0.25 (0.04–1.80) 0.93 (0.75–1.15) 0.50  
  HR per Q 1.00 (0.97–1.03) 0.93 (0.87–0.996) 0.63 (0.44–0.90)    
  P trend 0.89 0.038 0.010    
ZBED3 rs4457053        
  Q1 0.96 (0.81–1.13) 1.03 (0.86–1.23) 1.51 (1.14–2.01) 1.16 (1.02–1.31) 0.06 0.002
  Q2 0.96 (0.81–1.12) 1.00 (0.84–1.20) 1.04 (0.74–1.46) 1.03 (0.90–1.17) 0.36  
  Q3 1.04 (0.89–1.21) 1.04 (0.88–1.24) 0.85 (0.59–1.22) 0.99 (0.87–1.12) 0.97  
  Q4 0.93 (0.79–1.09) 0.93 (0.78–1.12) 0.67 (0.46–0.99) 0.95 (0.83–1.10) 0.55  
  Q5 1 (ref) 0.98 (0.82–1.17) 0.72 (0.50–1.04) 0.94 (0.81–1.07) 0.25  
  HR per Q 1.01 (0.97–1.05) 0.98 (0.94–1.03) 0.85 (0.76–0.95)    
  P trend 0.69 0.40 0.003    
  1. HR hazard ratio, Q quintile
  2. aX designates the non-risk allele and R designates the risk allele
  3. bAdjusted for age and sex
  4. cAdjusted for age, sex, BMI, total energy intake, dietary assessment method, season, leisure-time physical activity, smoking, alcohol intake, and education