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Table 4 HR of incident type 2 diabetes by genotype and quintiles of fiber intake

From: Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes

  

Genotype

   
 

XX

XRa

RR

HR per R allele

P trend b

P interaction c

TCF7L2 rs7903146

      
 

Q1

1.16 (0.98–1.39)

1.58 (1.32–1.89)

1.56 (1.14–2.15)

1.24 (1.09–1.40)

0.001

0.034

 

Q2

1.13 (0.95–1.35)

1.52 (1.27–1.82)

1.92 (1.43–2.60)

1.26 (1.11–1.42)

0.0002

 
 

Q3

1.15 (0.97–1.37)

1.62 (1.36–1.93)

2.10 (1.60–2.77)

1.37 (1.22–1.55)

1 × 10−7

 
 

Q4

1.02 (0.85–1.22)

1.35 (1.12–1.62)

1.93 (1.48–2.58)

1.31 (1.15–1.49)

5 × 10−5

 
 

Q5

1 (ref)

1.70 (1.42–2.03)

2.00 (1.49–2.70)

1.47 (1.30–1.66)

2 × 10−9

 
 

HR per Q

0.97 (0.93–1.01)

0.99 (0.95–1.03)

1.05 (0.95–1.15)

   
 

P trend c

0.19

0.64

0.37

   

TCF7L2 rs12255372

      
 

Q1

1.22 (1.03–1.45)

1.44 (1.20–1.73)

1.27 (0.90–1.78)

1.08 (0.95–1.22)

0.26

0.005

 

Q2

1.16 (0.98–1.38)

1.32 (1.10–1.58)

1.74 (1.31–2.32)

1.16 (1.02–1.31)

0.02

 
 

Q3

1.07 (0.90–1.28)

1.53 (1.29–1.82)

1.89 (1.44–2.47)

1.36 (1.21–1.53)

3 × 10−7

 
 

Q4

1.02 (0.86–1.22)

1.27 (1.05–1.52)

1.68 (1.25–2.26)

1.23 (1.08–1.40)

0.002

 
 

Q5

1 (ref)

1.41 (1.18–1.68)

1.99 (1.48–2.67)

1.40 (1.23–1.59)

4 × 10−7

 
 

HR per Q

0.96 (0.92–1.00)

0.98 (0.94–1.02)

1.05 (0.96–1.16)

   
 

P trend

0.060

0.37

0.28

   

NOTCH2 rs10923931

       
 

Q1

1.00 (0.87–1.14)

1.14 (0.92–1.42)

1.66 (0.86–3.23)

1.12 (0.93–1.34)

0.24

0.017

 

Q2

1.00 (0.88–1.14)

1.04 (0.85–1.28)

0.76 (0.28–2.04)

1.06 (0.88–1.28)

0.51

 
 

Q3

1.03 (0.91–1.18)

1.10 (0.90–1.35)

1.05 (0.47–2.34)

1.08 (0.90–1.30)

0.41

 
 

Q4

0.97 (0.85–1.11)

0.70 (0.55–0.90)

0.75 (0.28–2.00)

0.75 (0.60–0.95)

0.015

 
 

Q5

1 (ref)

1.00 (0.80–1.25)

0.25 (0.04–1.80)

0.93 (0.75–1.15)

0.50

 
 

HR per Q

1.00 (0.97–1.03)

0.93 (0.87–0.996)

0.63 (0.44–0.90)

   
 

P trend

0.89

0.038

0.010

   

ZBED3 rs4457053

       
 

Q1

0.96 (0.81–1.13)

1.03 (0.86–1.23)

1.51 (1.14–2.01)

1.16 (1.02–1.31)

0.06

0.002

 

Q2

0.96 (0.81–1.12)

1.00 (0.84–1.20)

1.04 (0.74–1.46)

1.03 (0.90–1.17)

0.36

 
 

Q3

1.04 (0.89–1.21)

1.04 (0.88–1.24)

0.85 (0.59–1.22)

0.99 (0.87–1.12)

0.97

 
 

Q4

0.93 (0.79–1.09)

0.93 (0.78–1.12)

0.67 (0.46–0.99)

0.95 (0.83–1.10)

0.55

 
 

Q5

1 (ref)

0.98 (0.82–1.17)

0.72 (0.50–1.04)

0.94 (0.81–1.07)

0.25

 
 

HR per Q

1.01 (0.97–1.05)

0.98 (0.94–1.03)

0.85 (0.76–0.95)

   
 

P trend

0.69

0.40

0.003

   
  1. HR hazard ratio, Q quintile
  2. aX designates the non-risk allele and R designates the risk allele
  3. bAdjusted for age and sex
  4. cAdjusted for age, sex, BMI, total energy intake, dietary assessment method, season, leisure-time physical activity, smoking, alcohol intake, and education
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Genes & Nutrition

ISSN: 1865-3499

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