Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study

Genes & Nutrition

Table 5 miRPath analysis of Hsa-mir-31-5p interactions

(A) KEGG-predicted pathway derived from DIANA-microT-CDS database	p value	genes
Metabolism of xenobiotics by cytochrome P450	1.46E-07	3
Inositol phosphate metabolism	0.00442	4
Fatty acid metabolism	0.02773	2
(B) KEGG-predicted targets provided by the DIANA-TarBase v6.0 database	p value	genes
Regulation of actin cytoskeleton	6.24E-06	5
Bacterial invasion of epithelial cells	1.79E-05	3
Axon guidance	8.85E-05	3
Shigellosis	0.00062	2
Pathogenic Escherichia coli infection	0.00276	2
Chemokine signaling pathway	0.00653	3
Pertussis	0.00746	2
Hypertrophic cardiomyopathy (HCM)	0.00979	2
Dilated cardiomyopathy	0.01157	2
T cell receptor signaling pathway	0.01604	2
Leukocyte transendothelial migration	0.01604	2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	0.01604	2
Dorso-ventral axis formation	0.03214	1

miRPath analysis of miR-31-5p (A) of predicted targets provided by the DIANA-microT-CDS algorithm or (B) of experimentally validated miRNA interactions derived from the DIANA-TarBase v6.0. Target pathways were classified according to KEGG functional annotations

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