Differences in genome-wide gene expression response in peripheral blood mononuclear cells between young and old men upon caloric restriction

Table 3 Pathways changed in PBMC gene expression profiles of young and old men before and upon 3 weeks of 30 % CR

Pathway	Baseline (old vs young)	Young men	Old men
RNA processing	↓	↑	↑
Cell cycle	–	↑/↓^a	↑/–^a
Oxidative stress	–	↓	↓
Immune response	↑	↓	–
Glucose metabolism	–	↓	–
Olfactory signalling	–	–	↓

↓ downregulated, ↑ upregulated, – no change
^aPart of gene sets classified under these pathways were upregulated, whereas others where downregulated

ISSN: 1865-3499