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Table 1 HR of incident CVD, coronary event, and ischemic stroke per 1 SD increase of GRS

From: Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort

GRSs

Total CVD

Coronary event

Ischemic stroke

Cases n men = 1759/n women = 1309

Cases n men = 1129/n women = 685

Cases n men = 630/n women = 624

Model 1a

Model 2b

Model 1

Model 2

Model 1

Model 2

GRSLDL-C

 All

1.09 (1.05–1.13)

1.08 (1.04–1.12)

1.09 (1.04–1.15)

1.08 (1.03–1.14)

1.07 (1.01–1.13)

1.07 (1.01–1.14)

 Men

1.08 (1.03–1.13)

1.07 (1.02–1.12)

1.08 (1.02–1.14)

1.07 (1.01–1.14)

1.07 (0.99–1.16)

1.07 (0.99–1.16)

 Women

1.10 (1.04–1.16)

1.09 (1.03–1.15)

1.13 (1.05–1.22)

1.11 (1.03–1.20)

1.07 (0.99–1.16)

1.07 (0.99–1.16)

GRSHDL-C

 All

1.05 (1.01–1.08)

1.03 (1.00–1.07)

1.03 (0.99–1.08)

1.00 (0.95–1.05)

1.06 (1.00–1.12)

1.08 (1.01–1.14)

 Men

1.03 (0.98–1.08)

1.01 (0.96–1.06)

1.01 (0.95–1.07)

0.97 (0.91–1.04)

1.06 (0.98–1.15)

1.08 (0.99–1.18)

 Women

1.07 (1.01–1.13)

1.06 (1.00–1.13)

1.08 (1.00–1.16)

1.05 (0.97–1.14)

1.06 (0.98–1.14)

1.07 (0.98–1.17)

GRSTG

 All

1.03 (1.00–1.07)

1.00 (0.96–1.04)

1.07 (1.02–1.12)

1.05 (1.00–1.10)

0.99 (0.93–1.04)

0.94 (0.88–1.00)

 Men

1.03 (0.99–1.08)

1.02 (0.96–1.07)

1.06 (1.00–1.13)

1.06 (1.00–1.14)

0.98 (0.91–1.06)

0.94 (0.86–1.02)

 Women

1.03 (0.98–1.09)

0.98 (0.93–1.04)

1.07 (0.99–1.15)

1.02 (0.94–1.11)

0.99 (0.91–1.07)

0.94 (0.86–1.03)

  1. Cox proportional hazard regression model was used to calculate HRs (95 % CI), among 9383 men and 15,416 women in the Malmö Diet and Cancer cohort
  2. aModel 1 is adjusted for age and sex
  3. bModel 2 is adjusted for age, sex, and the two GRSs simultaneously