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Table 2 HR in strata of diet quality index on incident CVD, coronary event, and ischemic stroke

From: Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort

 

Diet quality index

P interactiona

Low

Medium

High

n = 3360

n = 15,538

n = 2833

 

HR (95 % CI)

HR (95 % CI)

HR (95 % CI)

 

Total CVD

530 cases

2186 cases

352 cases

 

 GRSLDL-C

1.11 (1.02–1.21)

1.09 (1.04–1.14)

1.07 (0.96–1.19)

0.39 (0.86)b

 GRSHDL-C

1.08 (0.99–1.18)

1.03 (0.99–1.07)

1.10 (0.99–1.22)

0.85 (0.58)

 GRSTG

1.02 (0.93–1.11)

1.03 (0.99–1.08)

1.05 (0.95–1.17)

0.86 (0.20)

Coronary event

Cases n = 313

Cases n = 1285

Cases n = 216

 

 GRSLDL-C

1.13 (1.01–1.26)

1.08 (1.02–1.14)

1.15 (1.01–1.32)

0.33 (0.08)

 GRSHDL-C

1.02 (0.91–1.14)

1.03 (0.97–1.08)

1.11 (0.97–1.27)

0.35 (0.78)

 GRSTG

1.06 (0.95–1.19)

1.06 (1.01–1.12)

1.09 (0.95–1.25)

0.78 (0.23)

Ischemic stroke

Cases n = 217

Cases n = 901

Cases n = 136

 

 GRSLDL-C

1.08 (0.95–1.24)

1.10 (1.03–1.17)

0.93 (0.79–1.10)

0.01 (0.07)

 GRSHDL-C

1.16 (1.02–1.33)

1.04 (0.97–1.11)

1.07 (0.91–1.26)

0.18 (0.21)

 GRSTG

0.96 (0.84–1.10)

0.99 (0.93–1.06)

0.99 (0.83–1.17)

0.98 (0.59)

  1. Cox proportional hazard regression was used to calculate HRs (95 % CI) per 1 SD increase of the GRSs, P < 0.05, adjusted for age and sex among 24,799 participants in the Malmö Diet and Cancer cohort
  2. a P interactions (GRSs × diet quality index as continuous variables) adjusted for age, sex, BMI, diet assessment method version, season, total energy intake, alcohol habits, leisure time physical activity, educational level, and smoking habits
  3. b P values in parentheses are sensitivity analyses excluding those reporting dietary changes in the past and potential energy misreporters, n = 16,030