Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup’ik people

Table 3 Significant associations under the linkage peaks

SNP	Chr	Gene	P (additive)^a	P (full)^b	χ ² (LRT)^c	P (LRT)^c
25(OH)D
rs10205487/rs897119^d	2	MXD1	0.22	0.0006	18.15	0.0004
rs10828183	10	NEBL	0.0005	0.004	3.18	0.37
Parathyroid hormone
rs1353894	3	FNDC3B	0.03	0.0008	14.21	0.003

^a P value for the model including age, sex, community group, δ¹⁵N quartiles, and additive genotype
^b P value for the model including all of the above plus the interaction term between the additive genotype and δ¹⁵N quartiles
^cChi-square statistic and P value for the likelihood ratio test comparing the additive model with the full model
^drs10205487 and rs897119 were found to be in perfect linkage disequilibrium, with identical estimates of association signal

ISSN: 1865-3499