Fig. 3

Distinctive functional network of genes in normal renal development during postnatal life. a Functional network of gene sets of CON 1W (4 weeks old; infant) and CON 4W (7 weeks old; juvenile). Gene ontology (GO) was categorized based on Ingenuity Pathway Analysis (IPA) knowledge. GO terms in bold with asterisk indicate enriched biological functions in gene set enrichment analysis. Each node represents a biological function and its color and size indicate the p value and number of genes in the cluster, respectively. b Identification of significant genes related to postnatal renal development. c The increasing transcript levels of aquaporin family with age support that functional maturation were taking place in the kidneys of infant and juvenile mice. UB ureteric bud, GBM glomerular basement membrane, EMT epithelial-mesenchymal transition. Data are expressed as mean ± SEM. Student’s t test; *p < 0.05, **p < 0.01, ***p < 0.001