Fig. 3
From: Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature
Processes and consequences contributing to the genomic instability of the cell. Altered DNA synthesis, DNA repair and DNA methylation compromise the genomic stability of the cell. DNA damage and chromosomal abnormalities result from an incorrect assembly of DNA and the inability to repair errors efficiently, potentially affecting the next generation of cells or leading to cell death. If DNA methylation is disrupted, epigenetic changes affecting gene expression can occur, including incorrect methylation patterns or changes in chromatin structure