Skip to main content

Table 2 Association between 10 selected genetic variants and the risk of excess weight (p ≥85.0th) in young people aged 10 to 18 years

From: Examining for an association between candidate gene polymorphisms in the metabolic syndrome components on excess weight and adiposity measures in youth: a cross-sectional study

     

Part A

Part B

 

Region

Genetic variant

GENE

A2/A1

TEST

OR*

SE

95% CI

p value

OR†

SE

95% CI

p value

Risk allele

1q42.21

rs699

AGT

C/T

ADD

1.25

0.108

1.011, 1.545

0.0394

1.31

0.137

1.005, 1.720

0.0458

T

    

DOM

1.36

0.156

1.005, 1.855

0.0449

1.46

0.183

1.021, 2.097

0.0383

 
    

REC

1.29

0.205

0.865, 1.929

0.2108

1.42

0.248

0.873, 2.313

0.1575

 

2q37.3

rs3842570

CAPN10

IND/DEL

ADD

0.90

0.104

0.730, 1.099

0.2950

0.86

0.126

0.673, 1.108

0.2489

–

    

DOM

0.86

0.156

0.632, 1.165

0.3324

0.76

0.190

0.530, 1.117

0.1680

 
    

REC

0.87

0.189

0.601, 1.260

0.4612

0.87

0.221

0.564, 1.345

0.5333

 

8p21.3

rs285

LPL

C/T

ADD

1.11

0.102

0.910, 1.356

0.3009

1.19

0.124

0.934, 1.521

0.1572

–

    

DOM

1.33

0.169

0.955, 1.854

0.0939

1.58

0.199

1.071, 2.341

0.0212

 
    

REC

0.10

0.171

0.712, 1.394

0.9822

1.021

0.205

0.682, 1.526

0.9213

 

9q31.1

rs2230806

ABCA1

G/A

ADD

1.11

0.109

0.899, 1.379

0.3308

1.03

0.139

0.788, 1.362

0.7985

–

    

DOM

1.31

0.154

0.968, 1.770

0.0756

1.25

0.181

0.882, 1.798

0.2037

 
    

REC

0.88

0.222

0.573, 1.369

0.5836

0.91

0.256

0.554, 1.515

0.7348

 

10q25.2

rs7903146

TCF7L2

C/T

ADD

0.99

0.121

0.783, 1.260

0.9603

0.76

0.187

0.530, 1.106

0.1554

–

    

DOM

1.04

0.149

0.775, 1.390

0.8100

0.87

0.175

0.618, 1.228

0.4318

 
    

REC

0.81

0.322

0.432, 1.523

0.5140

0.60

0.367

0.293, 1.242

0.1706

 

11q13.4

rs1800849

UCP3

C/T

ADD

0.96

0.165

0.697, 1.332

0.8220

1.24

0.419

0.545, 2.826

0.6061

–

    

DOM

0.95

0.178

0.672, 1.351

0.7911

1.10

0.210

0.729, 1.660

0.6494

 
    

REC

1.07

0.6915

0.276, 4.159

0.9196

1.51

0.837

0.293, 7.820

0.6202

 

13q34

rs1805097

IRS2

G/A

ADD

0.77

0.1123

0.622, 0.966

0.0222

0.95

0.144

0.718, 1.265

0.7405

G

    

DOM

0.67

0.1502

0.502, 0.905

0.0090

0.71

0.176

0.506, 1.012

0.0582

 
    

REC

0.85

0.2253

0.546, 1.321

0.4691

1.12

0.271

0.657, 1.909

0.6757

 

16q12.2

rs17817449

FTO

T/G

ADD

1.17

0.1133

0.933, 1.455

0.1701

1.14

0.153

0.849, 1.548

0.3702

–

    

DOM

1.17

0.1478

0.875, 1.561

0.2887

1.07

0.173

0.761, 1.503

0.6968

 
    

REC

1.36

0.2527

0.832, 2.239

0.2186

1.30

0.294

0.732, 2.322

0.3677

 

16q13

rs708272

CETP

C/T

ADD

0.92

0.1107

0.741, 1.144

0.4594

0.94

0.135

0.727, 1.239

0.7021

–

    

DOM

0.83

0.1514

0.619, 1.120

0.2306

0.82

0.178

0.584, 1.174

0.2899

 
    

REC

1.06

0.2168

0.692, 1.618

0.7945

1.01

0.252

0.617, 1.659

0.0622

 

17q23.3

rs4340

ACE

IN/DEL

ADD

0.95

0.1029

0.781, 1.169

0.6571

0.96

0.120

0.762, 1.222

0.7669

–

    

DOM

0.98

0.1686

0.706, 1.367

0.9270

1.00

0.197

0.681, 1.475

0.9902

 
    

REC

0.90

0.1708

0.643, 1.257

0.5349

0.90

0.199

0.612, 1.339

0.6208

 
  1. The ORs are based on the major allele homozygotes as reference. The significant p values (p < 0.05) are given in bold type
  2. A2 major allele, A1 minor allele, ADD additive (major allele homozygotes vs. heterozygotes vs. minor allele homozygotes), DOM dominant (major allele homozygotes vs. heterozygotes + minor allele homozygotes), REC recessive (major allele homozygotes + heterozygotes vs. minor allele homozygotes), OR odds ratio, CI confidence interval
  3. *Adjusted for age, gender, and pubertal maturation
  4. †Adjusted for age, gender, pubertal maturation, and individual ancestry proportions
Back to article page

Genes & Nutrition

ISSN: 1865-3499

Contact us