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Fig. 1 | Genes & Nutrition

Fig. 1

From: Dietary and health biomarkers—time for an update

Fig. 1

A schematic overview of a framework supporting the development of dietary biomarkers. Ontology and classification scheme serve as the tools to navigate the targeted class of biomarkers. For each specific class of biomarkers, literature search would be conducted to provide reviews of the current state of knowledge on putative biomarkers. Putative biomarkers may also be identified by new explorative research. Candidate biomarkers are selected from the putative biomarkers by removing implausible entries based on literature. A validation scheme is applied on the candidate biomarkers to assess their validity by a defined set of criteria to identify the most promising candidate biomarkers as partially or fully validated for a specified use. Further validation studies may be used to systematically validate the best candidate biomarkers. All the available information is shared in public databases to support further studies on the development of biomarkers

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