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Table 2 The selected features for the four axes of the health space

From: Ranges of phenotypic flexibility in healthy subjects

Glucose

Coefficients

Lipid

Coefficients

AA and Vit

Coefficients

Metabolic stress

Coefficients

C-peptide (AUCp)

0.062

LDL (t0)

0.060

D-Glutamic acid (t0)

0.054

LDL (t0)

0.060

Total carbohydrates (Q)

− 0.060

Body fat %

0.059

L-Tyrosine (t0)

0.040

Cholesterol (t0)

0.059

Polysaccharides (Q)

− 0.058

Cholesterol (t0)

0.059

L-Isoleucine (AUCp)

0.040

Systolic blood pressure

0.055

Glucose (t0)

0.055

Waist circumference

0.055

Vitamin C index

0.038

Current weight (Q)

0.046

4-Methyl-2-oxovaleric-acid (t0)

− 0.052

BMI

0.055

Fisher ratio

− 0.036

GGTP (t0)

0.041

3-Methyl-2-oxo-valeric-acid (t0)

− 0.049

Systolic blood pressure

0.054

Iron index

− 0.035

Diastolic blood pressure

0.041

Insulin (AUCp)

0.045

Diastolic blood pressure

0.040

L-Phenylalanine (AUCp)

0.035

Triglyceride (AUCp)

0.040

Matsuda index

− 0.045

Triglyceride (AUCp)

0.040

L-Leucine (AUCp)

0.035

Triglyceride (t0)

0.038

L-Isoleucine (AUCp)

0.045

Triglyceride (t0)

0.038

Albumin (t0)

− 0.034

Education (Q)

− 0.038

Mono- and disaccharides (Q)

− 0.044

Body weight

0.037

D-Glutamic acid (AUCn)

− 0.033

Glucose (t0)

0.037

Hepatic insulin resistance (HC)

0.041

Waist-hip ratio

0.037

Vitamin B6 (Q)

− 0.033

L-Tyrosine (t0)

0.031

Glucose (AUCp)

0.040

Triglyceride (AUCn)

0.028

Phenylalanine hydroxylase activity index

0.033

Matsuda index

− 0.031

L-Leucine (AUCp)

0.039

Total fat (Q)

− 0.023

AAA

0.032

Alcohol (Q)

− 0.029

3-Methyl-2-oxo-valeric-acid (AUCn)

0.032

3-Hydroxybutanoic acid (AUCp)

− 0.016

Vitamin B1 (Q)

− 0.031

Triglyceride (AUCn)

0.029

Glucagon (AUCp)

0.030

  

Albumin (AUCn)

0.029

Fisher ratio

− 0.028

L-Valine (AUCp)

0.029

  

L-Lysine (t0)

0.029

Glucose (AUCp)

0.027

4-Methyl-2-oxovaleric-acid (AUCn)

0.026

  

L-Methionine (t0)

− 0.027

L-Phenylalanine (AUCp)

0.027

Glucagon (AUCn)

0.024

  

L-Valine (AUCp)

0.026

Albumin (t0)

− 0.026

    

Creatinine (AUCn)

0.025

Smoking (Q)

− 0.024

    

L-Tyrosine (AUCp)

0.025

Allergy (Q)

− 0.024

    

L-Ornithine (t0)

0.025

Albumin (AUCn)

0.023

    

Vitamin B2 (Q)

− 0.024

Glucose (AUCn)

− 0.022

    

Glycine (AUCp)

− 0.023

ALP (t0)

0.021

    

L-Serine (AUCp)

− 0.022

L-Tyrosine (AUCp)

0.019

    

Glycine (AUCn)

− 0.021

4-oxoproline (AUCp)

− 0.018

    

Total protein (Q)

− 0.021

  
    

Folic acid (Q)

− 0.021

  
    

L-Valine (AUCn)

0.021

  
    

Threonine (AUCp)

− 0.020

  
    

Albumin (AUCp)

0.019

  
    

L-Leucine (AUCn)

0.018

  
    

L-Phenylalanine (AUCn)

0.018

  
    

L-Serine (t0)

− 0.018

  
    

L-Proline (AUCn)

0.016

  
    

L-Tyrosine (AUCn)

0.016

  
    

L-Asparagine (t0)

− 0.015

  
    

L-Asparagine (AUCp)

− 0.015

  
    

Nonessential AA

0.014

  
  1. Coefficients represent relative weights for the features, indicating importance for separation of reference groups. AUCp refers to positive part of AUC, AUCn to negative part of AUC, t0 to fasting measurements, and Q to questionnaire