Skip to main content

Table 2 Effect of the dietary intervention on participants stratified by 599 C>T GPX1 (rs1050450) polymorphisms and interaction between period and group

From: Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention

599C>T GPX1 (rs1050450)
     Interaction
   CC (n = 36) CT + TT (n = 56) p 1 F p 2
BMI (kg/m2) Before 33 ± 5 31 35 ± 5 33 0.001 0.68 0.412
After 30 ± 3 30a** 33 ± 4 32a** 0.003   
SBP (mgHg) Before 120 ± 9120 124 ± 10,120 0.117 0.17 0.684
After 114 ± 13120a** 119 ± 13120a** 0.049   
DBP (mgHg) Before 85 ± 14 79 88 ± 8.9 88 0.375 21.19 < 0.001
After 77 ± 8.4 75 79 ± 7.1 79a** 0.011   
TBARS (mg/dl) Before 1.61 ± 0.61 1.40 1.34 ± 0.61 1.32 0.031 2.71 0.103
After 1.08 ± 0.42 1.06a** 1.01 ± 0.45 1.02a* 0.611   
Glucose (mg/dl) Before 127 ± 73,104 126 ± 68,105 0.600 0.79 0.374
After 102 ± 29 99a** 105 ± 25 99a** 0.990   
Total cholesterol (mg/dl) Before 176 ± 57,161 169 ± 34,169 0.489 1.11 0.295
After 159 ± 43,152 150 ± 27 150b** 0.384   
LDL-C (mg/dl) Before 117.9 ± 52.1107 126.5 ± 50.4125 0.174 0.01 0.914
After 93.7 ± 35.8 89a** 102.6 ± 38.9 95.5a** 0.347   
Triglycerides (mg/dl) Before 163.1 ± 32.3157 154.8 ± 39.2147 0.153 0.05 0.822
  After 161 ± 73.5 156a* 149 ± 48.7138 0.660   
Atherogenic index Before 4.5 ± 3.3 4 4.1 ± 1.1 4.3 0.955 2.52 0.116
After 3.8 ± 1.5 3.5 3.6 ± 1.4 3.3a* 0.033   
  1. Data show: mean ± SD median, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TBARS thiobarbituric acid-reactive substances, LDL-C low-density lipoprotein. p1 p value of the comparison between groups (wild type and carriers) before and after the intervention. Mann-Whitney U test or two-sample t test was used to compare groups. p2 p value of the interaction. Interaction was calculated with two-way ANOVA with replication
  2. *p < 0.05, **p < 0.001
  3. aWilcoxon signed-rank test was used to compare between before and after the intervention in the same group
  4. bPaired t test was used to compare between before and after the intervention in the same group