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Table 2 Effect of the dietary intervention on participants stratified by 599 C>T GPX1 (rs1050450) polymorphisms and interaction between period and group

From: Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention

599C>T GPX1 (rs1050450)

    

Interaction

  

CC (n = 36)

CT + TT (n = 56)

p 1

F

p 2

BMI (kg/m2)

Before

33 ± 5 31

35 ± 5 33

0.001

0.68

0.412

After

30 ± 3 30a**

33 ± 4 32a**

0.003

  

SBP (mgHg)

Before

120 ± 9120

124 ± 10,120

0.117

0.17

0.684

After

114 ± 13120a**

119 ± 13120a**

0.049

  

DBP (mgHg)

Before

85 ± 14 79

88 ± 8.9 88

0.375

21.19

< 0.001

After

77 ± 8.4 75

79 ± 7.1 79a**

0.011

  

TBARS (mg/dl)

Before

1.61 ± 0.61 1.40

1.34 ± 0.61 1.32

0.031

2.71

0.103

After

1.08 ± 0.42 1.06a**

1.01 ± 0.45 1.02a*

0.611

  

Glucose (mg/dl)

Before

127 ± 73,104

126 ± 68,105

0.600

0.79

0.374

After

102 ± 29 99a**

105 ± 25 99a**

0.990

  

Total cholesterol (mg/dl)

Before

176 ± 57,161

169 ± 34,169

0.489

1.11

0.295

After

159 ± 43,152

150 ± 27 150b**

0.384

  

LDL-C (mg/dl)

Before

117.9 ± 52.1107

126.5 ± 50.4125

0.174

0.01

0.914

After

93.7 ± 35.8 89a**

102.6 ± 38.9 95.5a**

0.347

  

Triglycerides (mg/dl)

Before

163.1 ± 32.3157

154.8 ± 39.2147

0.153

0.05

0.822

 

After

161 ± 73.5 156a*

149 ± 48.7138

0.660

  

Atherogenic index

Before

4.5 ± 3.3 4

4.1 ± 1.1 4.3

0.955

2.52

0.116

After

3.8 ± 1.5 3.5

3.6 ± 1.4 3.3a*

0.033

  
  1. Data show: mean ± SD median, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TBARS thiobarbituric acid-reactive substances, LDL-C low-density lipoprotein. p1 p value of the comparison between groups (wild type and carriers) before and after the intervention. Mann-Whitney U test or two-sample t test was used to compare groups. p2 p value of the interaction. Interaction was calculated with two-way ANOVA with replication
  2. *p < 0.05, **p < 0.001
  3. aWilcoxon signed-rank test was used to compare between before and after the intervention in the same group
  4. bPaired t test was used to compare between before and after the intervention in the same group
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Genes & Nutrition

ISSN: 1865-3499

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