Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention

Hernández-Guerrero, César; Parra-Carriedo, Alicia; Ruiz-de-Santiago, Diana; Galicia-Castillo, Oscar; Buenrostro-Jáuregui, Mario; Díaz-Gutiérrez, Carmen

doi:10.1186/s12263-017-0590-2

Table 3 Effect of the dietary intervention on participants stratified by − 251 A>G SOD1 (rs2070424) and 47C>T SOD2 (rs4880) polymorphisms, and interaction between period and group

From: Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention

		− 251A>G SOD1 (rs2070424)						47C>T SOD2 (rs4880)
					Interaction					Interaction
		AA (n = 53)	AG + GG (n = 39)	p ¹	F	p ²	CC (n = 30)	TC + TT (n = 62)	p ¹	F	p ²
BMI (kg/m²)	Before	34 ± 4.9 33	32 ± 4.5 30	0.021	0.32	0.570	35 ± 4.1 32	34 ± 4.8 33	0.047	105.37	< 0.001
BMI (kg/m²)	After	33 ± 4.2 31 ^a**	31 ± 3.8 30 ^a**	0.009			32 ± 5 31 ^a*	32 ± 4.1 31 ^a**	0.105
SBP (mgHg)	Before	124 ± 9.8120	120 ± 8.9119	0.082	8.88	0.004	122 ± 12,121	123 ± 7.7121	0.736	4.66	0.034
SBP (mgHg)	After	117 ± 11120 ^a**	113 ± 13120 ^a*	0.759			120 ± 13,120	113 ± 12 120 ^a**	0.594
DBP (mgHg)	Before	85 ± 10 84	89 ± 9 90	0.008	2.23	0.139	85 ± 9.8 85	87 ± 10 85	0.461	0.05	0.824
DBP (mgHg)	After	78 ± 7.9 76 ^a**	77 ± 6.8 79 ^a**	0.489			78 ± 9.1 78 ^a**	77 ± 6.4 76 ^a**	0.320
TBARS (mg/dl)	Before	1.41 ± 0.64 1.23	1.48 ± 0.57 1.41	0.429	0.26	0.614	1.30 ± 0.42 1.20	1.42 ± 0.65 1.30	0.443	6.59	0.012
TBARS (mg/dl)	After	1.09 ± 0.42 1.02 ^a**	1.11 ± 0.5 1.09 ^a**	0.446			1.18 ± 0.49 1.20	1.00 ± 0.47 1.05 ^a**	0.036
Glucose (mg/dl)	Before	135 ± 82,105	104 ± 25,103	0.254	1.47	0.229	127 ± 80,101	127 ± 60,102	0.223	0.31	0.576
Glucose (mg/dl)	After	107 ± 32 100 ^a**	98 ± 9.5 97 ^a**	0.040			106 ± 32 92 ^a**	101 ± 19 96 ^a**	0.009
Total cholesterol (mg/dl)	Before	174 ± 51,166	173 ± 38,169	0.613	0.85	0.358	170 ± 35,164	174 ± 43,175	0.747	7.87	0.006
Total cholesterol (mg/dl)	After	153 ± 40 146 ^a**	156 ± 30 153 ^a*	0.265			156 ± 36,144	154 ± 39 153 ^a**	0.164
LDL-C (mg/dl)	Before	118 ± 52,105	125 ± 41,122	0.275	0.00	0.954	108 ± 52 90	124 ± 43,123	0.066	10.95	0.001
LDL-C (mg/dl)	After	93 ± 36 84 ^a**	94 ± 31 92 ^a**	0.445			88 ± 32 79	96 ± 35 94 ^a**	0.527
Triglycerides (mg/dl)	Before	161 ± 42,152	149 ± 26,148	0.068	3.53	0.064	167 ± 43,159	151 ± 36,148	0.127	0.00	0.961
	After	167 ± 69,158	132 ± 43 122 ^a*	0.001			168 ± 59,150	154 ± 59,146	0.148
Atherogenic index	Before	4.7 ± 2.3 4.1	4.2 ± 1.0 4.2	0.853	3.30	0.073	4.4 ± 2.6 4.2	4.5 ± 1.6 4.1	0.543	2.49	0.118
Atherogenic index	After	4.0 ± 1.5 3.5	3.9 ± 1.3 3.8	0.138			4.3 ± 1.7 3.6	3.9 ± 1.4 3.4 ^a*	0.074

Data show: mean ± SD median, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TBARS thiobarbituric acid-reactive substances, LDL-C low-density lipoprotein. p¹ p value of the comparison between groups (wild type and carriers) before and after the intervention. Mann-Whitney U test or two-sample t test was used to compare groups. p² p value of the interaction. Interaction was calculated with two-way ANOVA with replication
^*p < 0.05, ^**p < 0.001
^aWilcoxon signed-rank test was used to compare between before and after the intervention in the same group
^bPaired t test was used to compare between before and after the intervention in the same group

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