Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention

Hernández-Guerrero, César; Parra-Carriedo, Alicia; Ruiz-de-Santiago, Diana; Galicia-Castillo, Oscar; Buenrostro-Jáuregui, Mario; Díaz-Gutiérrez, Carmen

doi:10.1186/s12263-017-0590-2

Table 4 Effect of the dietary intervention on participants stratified by − 21A>T CAT (rs7943316) and − 262C>T CAT (rs1001179) polymorphisms, and interaction between period and group

From: Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention

		− 21A>T CAT (rs7943316)					− 262C>T CAT (rs1001179)
					Interaction					Interaction
		AA (n = 24)	TA + TT (n = 68)	p ¹	F	p ²	CC (n = 55)	TC + TT (n = 37)	p ¹	F	p ²
BMI (kg/m²)	Before	31 ± 2 30	36 ± 5 33	< 0.001	0.38	0.541	35 ± 3 33	35 ± 6 33	0.412	0.02	0.881
BMI (kg/m²)	After	29 ± 2 28^a**	34 ± 4 31^a**	< 0.001			32 ± 3 30^a**	33 ± 5 30^a**	0.119
SBP (mgHg)	Before	122 ± 9120	121 ± 9.5120	0.992	4.48	0.037	123 ± 8.7122	119 ± 11,120	0.003	7.13	0.009
SBP (mgHg)	After	120 ± 9.6120	115 ± 13 119^a**	0.043			119 ± 11 121^a**	112 ± 14 119^a*	0.178
DBP (mgHg)	Before	89 ± 11 85	85 ± 9.9 85	0.225	10.37	0.002	85 ± 10 85	87 ± 9.7 87.5	0.860	0.47	0.492
DBP (mgHg)	After	75 ± 8.4 77^a**	78 ± 7.6 77^a**	0.186			77 ± 5.8 75^a**	78 ± 9.4 79^a**	0.320
TBARS (mg/dl)	Before	1.45 ± 0.6 1.38	1.43 ± 0.5 1.27	0.894	2.55	0.114	1.42 ± 0.6 1.21	1.42 ± 0.5 1.46	0.343	0.54	0.463
TBARS (mg/dl)	After	1.15 ± 0.5 1.27	1.04 ± 0.4 1.03^a**	0.006			1.3 ± 0.6 1.12^a*	0.97 ± 0.2 1.05^a**	0.108
Glucose (mg/dl)	Before	119 ± 26,105	129 ± 77,100	0.013	0.27	0.603	133 ± 80,104	111 ± 17,103	0.569	2.05	0.155
Glucose (mg/dl)	After	103 ± 9.1 98^a**	106 ± 27 98^a**	0.363			105 ± 30 96^a**	96 ± 9.7 96^a**	0.231
Total cholesterol (mg/dl)	Before	156.8 ± 37,155.5	177 ± 44,173.4	0.033	13.26	< 0.001	179 ± 51,178	165 ± 34,166	0.300	4.37	0.039
Total cholesterol (mg/dl)	After	155.1 ± 29,149	155.8 ± 40,147.6^a**	0.615			163 ± 43,156	145 ± 23 140^a**	< 0.001
LDL-C (mg/dl)	Before	105.6 ± 38 98	125 ± 49,126	0.038	1.79	0.184	136 ± 46,124	99 ± 43 90	< 0.001	22.96	< 0.001
LDL-C (mg/dl)	After	91.5 ± 32 83^a*	96.4 ± 38 94^a**	0.100			105 ± 37 95^a**	80 ± 35 78	0.240
Atherogenic index	Before	4.4 ± 1.6 4.3	4.4 ± 1.8 4.5	0.350	5.35	0.023	4.8 ± 1.5 4.3	3.9 ± 1.3 4.4	0.297	1.62	0.206
Atherogenic index	After	3.6 ± 1.5 3.8	3.7 ± 1.4 3.1^a**	0.049			4.1 ± 1.7 4.5	3.7 ± 1.3 3.6	0.006

Data show: mean ± SD median, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TBARS thiobarbituric acid reactive substances, LDL low density lipoprotein. p¹ p value of the comparison between groups (wild type and carriers) before and after the intervention. Mann-Whitney U test or two-sample t test was used to compare groups. p² p value of the interaction. Interaction was calculated with two-way ANOVA with replication
^*p < 0.05, ^**p < 0.001
^aWilcoxon signed-rank test was used to compare between before and after the intervention in the same group
^bPaired t test was used to compare between before and after the intervention in the same group

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