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Table 4 Effect of the dietary intervention on participants stratified by − 21A>T CAT (rs7943316) and − 262C>T CAT (rs1001179) polymorphisms, and interaction between period and group

From: Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention

   − 21A>T CAT (rs7943316) − 262C>T CAT (rs1001179)
     Interaction    Interaction
   AA (n = 24) TA + TT (n = 68) p 1 F p 2 CC (n = 55) TC + TT (n = 37) p 1 F p 2
BMI (kg/m2) Before 31 ± 2 30 36 ± 5 33 < 0.001 0.38 0.541 35 ± 3 33 35 ± 6 33 0.412 0.02 0.881
After 29 ± 2 28a** 34 ± 4 31a** < 0.001    32 ± 3 30a** 33 ± 5 30a** 0.119   
SBP (mgHg) Before 122 ± 9120 121 ± 9.5120 0.992 4.48 0.037 123 ± 8.7122 119 ± 11,120 0.003 7.13 0.009
After 120 ± 9.6120 115 ± 13 119a** 0.043    119 ± 11 121a** 112 ± 14 119a* 0.178   
DBP (mgHg) Before 89 ± 11 85 85 ± 9.9 85 0.225 10.37 0.002 85 ± 10 85 87 ± 9.7 87.5 0.860 0.47 0.492
After 75 ± 8.4 77a** 78 ± 7.6 77a** 0.186    77 ± 5.8 75a** 78 ± 9.4 79a** 0.320   
TBARS (mg/dl) Before 1.45 ± 0.6 1.38 1.43 ± 0.5 1.27 0.894 2.55 0.114 1.42 ± 0.6 1.21 1.42 ± 0.5 1.46 0.343 0.54 0.463
After 1.15 ± 0.5 1.27 1.04 ± 0.4 1.03a** 0.006    1.3 ± 0.6 1.12a* 0.97 ± 0.2 1.05a** 0.108   
Glucose (mg/dl) Before 119 ± 26,105 129 ± 77,100 0.013 0.27 0.603 133 ± 80,104 111 ± 17,103 0.569 2.05 0.155
After 103 ± 9.1 98a** 106 ± 27 98a** 0.363    105 ± 30 96a** 96 ± 9.7 96a** 0.231   
Total cholesterol (mg/dl) Before 156.8 ± 37,155.5 177 ± 44,173.4 0.033 13.26 < 0.001 179 ± 51,178 165 ± 34,166 0.300 4.37 0.039
After 155.1 ± 29,149 155.8 ± 40,147.6a** 0.615    163 ± 43,156 145 ± 23 140a** < 0.001   
LDL-C (mg/dl) Before 105.6 ± 38 98 125 ± 49,126 0.038 1.79 0.184 136 ± 46,124 99 ± 43 90 < 0.001 22.96 < 0.001
After 91.5 ± 32 83a* 96.4 ± 38 94a** 0.100    105 ± 37 95a** 80 ± 35 78 0.240   
Atherogenic index Before 4.4 ± 1.6 4.3 4.4 ± 1.8 4.5 0.350 5.35 0.023 4.8 ± 1.5 4.3 3.9 ± 1.3 4.4 0.297 1.62 0.206
After 3.6 ± 1.5 3.8 3.7 ± 1.4 3.1a** 0.049    4.1 ± 1.7 4.5 3.7 ± 1.3 3.6 0.006   
  1. Data show: mean ± SD median, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TBARS thiobarbituric acid reactive substances, LDL low density lipoprotein. p1 p value of the comparison between groups (wild type and carriers) before and after the intervention. Mann-Whitney U test or two-sample t test was used to compare groups. p2 p value of the interaction. Interaction was calculated with two-way ANOVA with replication
  2. *p < 0.05, **p < 0.001
  3. aWilcoxon signed-rank test was used to compare between before and after the intervention in the same group
  4. bPaired t test was used to compare between before and after the intervention in the same group