Analysis of circulating angiopoietin-like protein 3 and genetic variants in lipid metabolism and liver health: the DiOGenes study

Table 4 SNPs associated with circulating ANGPTL3 at baseline (p < 1 × 10⁻⁵)

SNP	Chr	Position (bp)	A1	A2	MAF	Coef.	se	p value
rs36000763	6	48,687,252	A	G	0.064	0.202	0.041	1.06 × 10⁻⁶
rs41528149	6	48,728,020	T	C	0.065	0.200	0.041	1.20 × 10⁻⁶
rs13185453	5	166,370,819	A	G	0.143	0.143	0.030	1.73 × 10⁻⁶
rs35976153	5	166,365,612	T	C	0.146	0.136	0.029	3.34 × 10⁻⁶
rs12334611	8	37,045,986	C	T	0.072	0.182	0.040	4.35 × 10⁻⁶
rs1277307	4	57,896,699	G	T	0.097	0.162	0.035	4.36 × 10⁻⁶
rs76263326	14	76,627,919	C	T	0.100	0.151	0.033	5.12 × 10⁻⁶
rs12100883	14	76,628,814	T	C	0.100	0.151	0.033	5.12 × 10⁻⁶
rs1900121	14	76,629,481	T	C	0.100	0.151	0.033	5.12 × 10⁻⁶
rs3783998	14	76,632,781	G	T	0.101	0.151	0.033	5.26 × 10⁻⁶
rs4903381	14	76,635,675	C	G	0.100	0.151	0.033	5.67 × 10⁻⁶
rs17521181	13	42,828,989	A	T	0.089	0.164	0.036	5.69 × 10⁻⁶
rs4739476	8	37,046,991	A	G	0.070	0.184	0.041	6.33 × 10⁻⁶
rs74528305	2	25,066,379	G	T	0.077	0.177	0.039	6.57 × 10⁻⁶
rs74571086	8	37,049,958	G	A	0.070	0.184	0.041	7.97 × 10⁻⁶

Results from the association between SNPs and ANGPTL3 level at baseline
A1 and A2 the minor and major alleles, bp basepair, Chr chromosome, Coef estimated association coefficient, MAF minor allele frequency, se standard error, SNP single nucleotide polymorphism

ISSN: 1865-3499