Analysis of circulating angiopoietin-like protein 3 and genetic variants in lipid metabolism and liver health: the DiOGenes study

Table 5 SNPs associated with change in circulating ANGPTL3 during weight loss intervention (p < 1 × 10⁻⁵)

SNP	Chr	Position (bp)	A1	A2	MAF	Coef.	se	p value
rs4360730*	11	116,488,748	C	T	0.057	0.166	0.032	2.48 × 10⁻⁷
rs74234276*	11	116,488,753	A	G	0.057	0.166	0.032	2.48 × 10⁻⁷
rs9994520*	4	154,882,844	G	C	0.304	0.084	0.016	2.93 × 10⁻⁷
rs113794502	20	23,631,539	G	C	0.237	− 0.091	0.018	3.33 × 10⁻⁷
rs7661078	4	154,883,600	A	G	0.302	0.083	0.016	3.78 × 10⁻⁷
rs55656752	20	23,631,510	A	T	0.236	− 0.090	0.018	5.01 × 10⁻⁷
rs112213361	20	23,631,523	A	G	0.236	− 0.090	0.018	5.01 × 10⁻⁷
rs73102376	20	23,633,232	T	C	0.234	− 0.090	0.018	5.53 × 10⁻⁷
rs73102379	20	23,633,245	C	T	0.234	− 0.090	0.018	5.53 × 10⁻⁷
rs73102363	20	23,631,599	G	C	0.236	− 0.089	0.018	5.78 × 10⁻⁷
rs73102364	20	23,631,602	G	A	0.236	− 0.089	0.018	5.78 × 10⁻⁷
rs73102366	20	23,631,654	T	C	0.236	− 0.089	0.018	5.78 × 10⁻⁷
rs60143382	20	23,631,067	A	G	0.236	− 0.090	0.018	5.84 × 10⁻⁷
rs55724037	20	23,631,068	C	T	0.236	− 0.090	0.018	5.84 × 10⁻⁷
rs58578197	20	23,631,309	C	T	0.236	− 0.090	0.018	5.84 × 10⁻⁷
rs112950650	20	23,632,409	G	A	0.235	− 0.089	0.018	6.05 × 10⁻⁷
rs8116240	20	23,632,730	T	C	0.235	− 0.089	0.018	6.05 × 10⁻⁷
rs8122969	20	23,632,847	C	T	0.235	− 0.089	0.018	6.05 × 10⁻⁷
rs8124308	20	23,633,094	C	T	0.235	− 0.089	0.018	6.17 × 10⁻⁷
rs8122922	20	23,632,776	C	T	0.236	− 0.089	0.018	6.50 × 10⁻⁷

Results from the association between SNPs and ANGPTL3 protein level change during weight loss intervention
A1 and A2 the minor and major alleles, bp basepair, Chr chromosome, Coef estimated association coefficient, MAF minor allele frequency, se standard error, SNP Single nucleotide polymorphism
*SNPs with adjusted p value < 0.10 upon the SLIDE (permutation) p value adjustments