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Table 7 Selected pathways identified in DAVID for differentially expressed target genes (DET) and their corresponding miRNAs

From: Effect of β-hydroxy-β-methylbutyrate on miRNA expression in differentiating equine satellite cells exposed to hydrogen peroxide

No. Pathway Pathway P value Number of genes Gene name Fold change FDR DET-related identified miRNA
1 RIG-I-like receptor signalling pathway 5.2E−04 8 ddx3x 1.59 ↑ 1.15E−2 miR-101 ↑, miR-1↓, miR-133a/b↓, miR-208↓
traf3 1.31 ↑ 1.11E−2 miR-30↓, miR-155↑, miR-133a/b↓
cxcl10 56.62 ↑ 2.16E−5 miR-142-3p↓
cyld 1.78 ↑ 1.19E−3 miR-30↓, miR-133a/b↓
ikbke 2.27 ↑ 2.44E−3 miR-155↑, miR-128↓
mapk14 1.68 ↑ 5.43E−3 miR-128↓, miR-101↑
map3k7 − 1.58 ↓ 4.02E−3 miR-30↓, miR-101↑, miR-155↑, miR-204↑
rnf125 1.88 ↑ 9.59E−3 miR-101↑, miR-142-3p↓
2 Hyper-trophy cardiomyopathy 1.5E−03 8 cacnb1 − 1.42 ↓ 1.10E−3 miR-204↑, miR-208↓
dag1 − 1.91 ↓ 4.43E−3 miR-142-3p↓, miR-101↑, miR-30↓
itga2 − 1.32 ↓ 7.08E−3 miR-30↓, miR-101↑, miR-128↓
itgav − 1.49 ↓ 6.71E−3 miR-142-3p↓
prkaa2 − 1.69 ↓ 5.03E−3 miR-30↓, miR-146a/b↑
sgcd 1.33 ↑ 1.34E−3 miR-142-3p↓
tpm1 − 1.85 ↓ 2.02E−4 miR-142-3p↓, miR-542↓
tpm3 − 2.87 ↓ 1.08E−2 miR-204↑, miR-221/222↑
3 MAPK signalling pathway 7.3E−03 13 bdnf − 2.08 ↓ 9.14E−4 miR-1↓, miR-206↓, miR-155↑, miR-30↓, miR-204↑
cacnb1 − 1.42 ↓ 1.10E−3 miR-204↑, miR-208↓
dusp1 1.77 ↑ 2.80E−3 miR-133a/b↓, miR-101↑
mecom 1.50 ↑ 1.34E−3 miR-1↓, miR-133a/b↓, miR-206↓, miR-142-3p↓
fgf11 − 1.36 ↓ 1.11E−2 miR-331↓
fgf7 5.83 ↑ 2.33E−3 miR-101↑, miR-155↑, miR-142-3p↓
mapk14 1.68 ↑ 5.43E−3 miR-128↓, miR-101↑
map3k7 − 1.58 ↓ 4.02E−3 miR-30↓, miR-101↑, miR-155↑, miR-204↑
map3k4 − 1.36 ↓ 9.06E−3 miR-101↑, miR-128↓
ntf3 1.72 ↑ 2.44E−3 miR-221/222↑
pla2g4a 2.27 ↑ 1.39E−3 miR-142-3p↓
dgfra 2.82 ↑ 1.47E−3 miR-142-3p↓
sos2 − 1.62 ↓ 9.09E−3 miR-208↓, miR-204↑, miR-221/222↑
4 p38 MAPK 9.9E−02 4 mapk14 1.68 ↑ 5.43E−3 miR-128↓, miR-101↑
map3k4 − 1.36 ↓ 9.01E−3 miR-101↑, miR-128↓
map3k7 −1.58 ↓ 4.02E−3 miR-30↓, miR-101↑, miR-155↑, miR-204↑
dusp1 1.77 ↑ 2.80E−3 miR-133a/b↓, miR-101↑
5 Toll-like receptor signalling pathway 1.6E−02 7 traf3 1.31 ↑ 1.11E−2 miR-30↓, miR-155↑, miR-133a/b↓
cxcl10 56.62 ↑ 2.16E−5 miR-142-3p↓
cxcl11 14.20 ↑ 9.51E−5 miR-1↓, miR-206↓
tlr4 1.44 ↑ 9.52E−4 miR-542↓, miR-374↑
ikbke 2.27 ↑ 2.44E−3 miR-155↑, miR-128↓
mapk14 1.68 ↑ 5.43E−3 miR-128↓, miR-101↑
map3k7 − 1.58 ↓ 4.02E−3 miR-30↓, miR-101↑, miR-155↑, miR-204↑
6 Ubiquitin-mediated proteolysis 2.0E−02 8 rhobtb2 − 1.62 ↓ 9.15E−3 miR-204↑, miR-133↓
cul3 − 1.71 ↓ 4.76E−5 miR-101↑, miR-193a↑
cul4b 1.58 ↑ 1.08E−3 miR-133a/b↓, miR-101↑
mid1 − 1.40 ↓ 1.01E−2 miR-374↓, miR-542-3p↓
nedd4 − 1.30 ↓ 1.00E−2 miR-30↓, miR-128↓
trim32 1.50 ↑ 1.13E−2 miR-155↑, miR-142-3p↓
ube2g1 − 1.41 ↓ 5.46E−4 miR-101↑, miR-30↓,
ube2h − 1.53 ↓ 3.80E−3 miR-1↓, miR-206↓, miR-204↑, miR-101↑
7 Ras pathway 3.4E−02 6 tiam2 − 1.44 ↓ 3.27E−3 miR-101↑
sos2 − 1.54 ↓ 9.09E−3 miR-193↑, miR-208↓,
ets1 1.98 ↑ 7.19E−3 miR-193↑, miR-208↑, miR-101↑, miR-221/222↑, miR-1↓, miR-206↓
mapk14 1.68 ↑ 5.43E−3 miR-128↓, miR-101↑
map3k7 − 1.58 ↓ 4.02E−3 miR-30↓, miR-101↑, miR-155↑, miR-204↑
map3k4 − 1.36 ↓ 9.01E3 miR-101↑, miR-128↓
8 Oxidative stress response 3.9E−02 5 dusp1 1.77 ↑ 2.80E−3 miR-133a/b↓, miR-101↑
dusp19 − 1.55 ↓ 2.09E−3 miR-204↑
mapk14 1.68 ↑ 5.43E−3 miR-128↓, miR-101↑
map3k4 − 1.36 ↓ 9.01E−3 miR-101↑, miR-128↓
pla2g4a 2.27 ↑ 1.39E−3 miR-142-3p↓
  1. MiRNAs in bold have the opposite expression change to corresponding DET. The arrows indicate the direction of expression change: ↓ and ↑ for down- and upregulation, respectively