From: Dietary and genetic risk scores and incidence of type 2 diabetes
 |  | All Tertile of genetic risk score |  | Women Tertile of genetic risk score |  | Men Tertile of genetic risk score |  | ||||||
 | n | 1 | 2 | 3 | P trend* | 1 | 2 | 3 | P trend* | 1 | 2 | 3 | P trend* |
Age (years) | 25,069 | 58.3 (7.8) | 58.2 (7.6) | 58.2 (7.7) | 0.32 | 57.3 (8.0) | 57.3 (7.9) | 57.3 (8.0) | 0.86 | 59.5 (7.2) | 59.0 (7.1) | 59.1 (7.1) | 0.04 |
BMI | 25,035 | 25.7 (4.0) | 25.7 (3.9) | 25.6 (3.8) | 0.12 | 25.3 (4.2) | 25.4 (4.2) | 25.3 4.0) | 0.48 | 26.2 (3.5) | 26.2 (3.4) | 26.0 (3.4) | 0.046 |
Fasting blood glucose (mmol/L) | 4860 | 4.90 (0.6) | 5.00 (0.7) | 5.05 (0.8) | < 0.001 | 4.78 (0.5) | 4.88 (0.6) | 4.94 (0.7) | < 0.001 | 5.06 (0.6) | 5.17 (0.8) | 5.21 (1.0) | 0.001 |
Fasting plasma insulin (mIU/L) | 4819 | 7.8 (8.9) | 7.7 (8.1) | 7.7 (6.1) | 0.89 | 7.3 (8.3) | 7.0 (5.0) | 7.2 (4.8) | 0.75 | 8.5 (9.5) | 8.7 (11.3) | 8.6 (7.4) | 0.93 |
HOMA-IR†| 4571 | 1.60 (1.43) | 1.59 (1.12) | 1.61 (1.13) | 0.76†| 1.49 (1.54) | 1.47 (1.04) | 1.49 (0.96) | 0.66†| 1.76 (1.23) | 1.77 (1.21) | 1.80 (1.32) | 0.29†|
Alcohol intake (g/day) ‡ | 23,551 | 11.6 (12.8) | 11.5 (12.9) | 11.3 (12.3) | 0.11 | 8.5 (8.9) | 8.3 (8.6) | 8.3 (8.7) | 0.21 | 16.4 (16.0) | 16.4 (16.4) | 15.9 (15.3) | 0.26 |
Processed meat (g/day) | 25,069 | 38 (30) | 38 (30) | 38 (30) | 0.61 | 31 (23) | 31 (23) | 31 (23) | 0.57 | 51 (35) | 49 (36) | 50 (36) | 0.68 |
Sugar-sweetened beverages (g/day) | 25,069 | 76 (145) | 78 (150) | 77 (145) | 0.64 | 67 (125) | 65 (121) | 66 (127) | 0.83 | 91 (171) | 99 (187) | 95 (170) | 0.42 |
Whole grain (portions/day) | 25,069 | 1.0 (1.0) | 1.0 (1.0) | 1.0 (1.0) | 0.93 | 0.9 (0.9) | 0.9 (0.9) | 0.9 (0.9) | 0.65 | 1.0 (1.2) | 1.1 (1.2) | 1.1 (1.2) | 0.58 |
Coffee (g/day) | 25,069 | 520 (390) | 530 (400) | 510 (400) | 0.77 | 510 (380) | 520 (390) | 510 (390) | 0.87 | 530 (400) | 540 (420) | 530 (410) | 0.77 |
 |  |  |  |  | P value |  |  |  | P value |  |  |  | P value |
Smoking (ever) (%) | 25,059 | 62.4 | 61.7 | 61.1 | 0.22 | 56.7 | 55.6 | 54.9 | 0.17 | 71.3 | 71.3 | 71.4 | 0.99 |
Leisure time physical activity, high (%)§ | 24,913 | 18.9 | 20.6 | 20.2 | 0.02 | 19.4 | 20.1 | 20.2 | 0.58 | 18.2 | 21.4 | 20.3 | 0.01 |
Education (> 10 years) (%) | 25,008 | 32.0 | 32.7 | 31.5 | 0.25 | 31.1 | 30.5 | 30.3 | 0.68 | 33.3 | 36.3 | 33.3 | 0.02 |
 |  | Diet risk score |  | Diet risk score |  | Diet risk score |  | ||||||
 | n | Low | Mid | High | P trend* | Low | Mid | High | P trend* | Low | Mid | High | P trend* |
n | Â | 5699 | 15,188 | 4182 | Â | 3767 | 9205 | 2408 | Â | 1932 | 5983 | 1774 | Â |
Age (years) | 25,069 | 57.6 (7.4) | 58.4 (7.7) | 58.7 (8.0) | < 0.001 | 56.6 (7.5) | 57.4 (8.0) | 57.8 (8.4) | < 0.001 | 58.6 (6.8) | 59.3 (7.1) | 59.6 (7.2) | < 0.001 |
BMI | 25,035 | 25.4 (3.8) | 25.6 (3.9) | 26.0 (4.0) | < 0.001 | 25.0 (3.9) | 25.3 (4.2) | 25.7 (4.2) | < 0.001 | 26.1 (3.3) | 26.1 (3.4)) | 26.6 (3.5) | < 0.001 |
Fasting blood glucose (mmol/L) | 4860 | 4.94 (0.7) | 4.98 (0.7) | 5.07 (0.9) | < 0.001 | 4.82 (0.5) | 4.89 (0.6) | 4.92 (0.7) | 0.005 | 5.13 (0.9) | 5.12 (0.7) | 5.28 (1.0) | 0.03 |
Fasting plasma insulin (mIU/L) | 4819 | 7.4 (7.3) | 7.7 (8.0) | 8.7 (7.6) | 0.001 | 7.0 (8.1) | 7.1 (5.4) | 7.7 (4.8) | 0.12 | 7.8 (5.4) | 8.6 (10.6) | 10.0 (9.8) | 0.002 |
HOMA-IR†| 4571 | 1.52 (1.49) | 1.58 (1.07) | 1.81 (1.35) | < 0.001 | 1.46 (1.68) | 1.46 (0.91) | 1.66 (1.14) | < 0.001 | 1.61 (1.04) | 1.77 (1.23) | 2.03 (1.54) | < 0.001 |
Alcohol intake (g/day)‡ | 23,551 | 11.5 (12.0) | 11.4 (12.6) | 11.7 (13.8) | 0.53 | 8.6 (8.5) | 8.4 (8.7) | 7.8 (8.9) | 0.007 | 15.9 (15.7) | 16.0 (15.7) | 17.4 (16.8) | 0.009 |
Processed meat (g/day) | 25,069 | 22 (21) | 40 (30) | 55 (31) | < 0.001 | 18 (16) | 32 (23) | 46 (24) | < 0.001 | 28 (26) | 51 (36) | 69 (36) | < 0.001 |
Sugar-sweetened beverages (g/day) | 25,069 | 18 (70) | 70 (140) | 170 (200) | < 0.001 | 12 (52) | 66 (124) | 150 (156) | < 0.001 | 25 (91) | 84 (161) | 209 (235) | < 0.001 |
Whole grain (portions/day) | 25,069 | 1.6 (1.2) | 0.9 (0.9) | 0.4 (0.5) | < 0.001 | 1.5 (0.9) | 0.8 (0.8) | 0.4 (0.4) | < 0.001 | 1.9 (1.4) | 1.0 (1.1) | 0.4 (0.5) | < 0.001 |
Coffee (g/day) | 25,069 | 700 (410) | 510 (390) | 310 (260) | < 0.001 | 680 (400) | 490 (370) | 310 (270) | < 0.001 | 735 (430) | 530 (410) | 320 (260) | < 0.001 |
 |  |  |  |  | P value |  |  |  | P value |  |  |  | P value |
Smoking (ever) (%) | 25,059 | 65.2 | 61.3 | 58.5 | < 0.001 | 60.7 | 55.0 | 50.6 | < 0.001 | 74.1 | 71.1 | 69.3 | < 0.004 |
Leisure time Physical Activity, high (%)§ | 24,913 | 22.3 | 19.3 | 18.9 | < 0.001 | 22.9 | 19.1 | 18.1 | < 0.001 | 21.2 | 19.5 | 19.8 | 0.30 |
Education (> 10 years) (%) | 25,008 | 37.7 | 31.6 | 26.3 | < 0.001 | 35.7 | 30.4 | 23.6 | < 0.001 | 41.8 | 33.3 | 29.9 | < 0.001 |