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Table 2 Hazard ratios of incident type 2 diabetes according to a genetic risk score, and according to a diet risk score and its components, in 15,380 women and 9689 men from the Malmö Diet and Cancer Study

From: Dietary and genetic risk scores and incidence of type 2 diabetes

 

All

Women

Men

  

Tertile*

   

Tertile*

   

Tertile*

  
 

1

2

3

P value for trend†

1

2

3

P value for trend†

1

2

3

P value for trend†

Cases/person-years

929/147393

1188/144429

1471/142031

 

478/92494

602/91511

764/91595

 

451/54897

586/52917

707/50436

 

Genetic risk score

1.00

1.31

1.21, 1.43

1.67

1.54, 1.81

7 × 10−35

1.00

1.28

1.13, 1.44

1.62

1.44, 1.81

1 × 10−16

1.00

1.36

1.20, 1.53

1.72

1.53, 1.94

9 × 10−20

Cases/person-years

673/102570

2194/262381

721/68902

 

350/69708

1154/164327

340/41567

 

323/32862

1040/98054

381/27336

 

Diet risk score

1.00

1.19

1.09, 1.30

1.40

1.26, 1.56

6 × 10−10

1.00

1.33

1.18, 1.50

1.45

1.26, 1.71

3 × 10−7

1.00

1.07

0.95, 1.22

1.33

1.14, 1.55

0.0002

Processed meat

1.00

1.01

0.93, 1.10

1.11

1.03, 1.21

0.009

1.00

1.06

0.95, 1.19

1.12

1.01, 1.27

0.03

1.00

0.98

0.87, 1.11

1.11

0.98, 1.25

0.08

SSB

1.00

1.01

0.93, 1.10

1.13

1.05, 1.22

0.003

1.00

1.06

0.94, 1.20

1.12

1.01, 1.25

0.03

1.00

0.95

0.84, 1.07

1.14

1.01, 1.28

0.06

Whole grain

1.00

0.94

0.86, 1.01

0.89

0.82, 0.96

0.004

1.00

0.95

0.85, 1.05

0.90

0.80, 1.02

0.09

1.00

0.92

0.82, 1.03

0.87

0.77, 0.98

0.02

Coffee

1.00

0.87

0.81, 0.95

0.75

0.69, 0.81

1 × 10−11

1.00

0.78

0.70, 0.87

0.63

0.56, 0.71

2 × 10−14

1.00

0.97

0.87, 1.10

0.88

0.78, 0.99

0.04

  1. *For the DRS the levels refer to low risk score (0–2 points), medium risk score (3–5 points) and high risk score (6–8 points) instead of tertiles
  2. †Age-stratified model, adjusted for sex when applicable. Examination of dietary variables was also adjusted for diet method version, season, total energy intake, BMI, leisure time physical activity, alcohol intake, smoking and education