Dietary and genetic risk scores and incidence of type 2 diabetes

Genes & Nutrition

Table 3 Hazard ratios of incident type 2 diabetes according to a weighted genetic risk score in strata of a diet risk score based on intakes of processed meat, sugar-sweetened beverages (SSB), whole grain and coffee in 15,380 women and 9689 men from the Malmö Diet and Cancer Study

	All				Women				Men
Diet risk score level/diet tertile	Tertile of genetic risk score			P value for trend*	Tertile of genetic risk score			P value for trend*	Tertile of genetic risk score			P value for trend*
Diet risk score level/diet tertile	1	2	3	P value for trend*	1	2	3	P value for trend*	1	2	3	P value for trend*
Diet risk score
Low	1.00	1.38 1.13, 1.68	1.71 1.41, 2.08	4 × 10⁻⁸	1.00	1.50 1.13, 1.99	1.75 1.34, 2.30	6 × 10⁻⁵	1.00	1.25 0.94, 1.68	1.69 1.28, 2.22	2 × 10⁻⁴
Medium	1.00	1.30 1.16, 1.45	1.66 1.49, 1.84	2 × 10⁻²¹	1.00	1.22 1.05, 1.43	1.62 1.40, 1.87	4 × 10⁻¹¹	1.00	1.40 1.19, 1.64	1.71 1.47, 2.00	8 × 10⁻¹²
High	1.00	1.32 1.09, 1.60	1.69 1.41, 2.03	1 × 10⁻⁸	1.00	1.26 0.96, 1.67	1.50 1.16, 1.96	0.002	1.00	1.39 1.07, 1.83	1.85 1.44, 2.38	2 × 10⁻⁶
P _interaction ^†,‡				0.83 (0.94)				0.40 (0.67)				0.60 (0.73)

*Age-stratified model, adjusted for sex when applicable
^†Age-stratified model, adjusted for sex, diet method version, season, total energy intake, BMI, leisure time physical activity, alcohol intake, smoking and education
^‡P for interaction treating tertiles as continuous variables and, in brackets, P for interaction between continuous variables of the GRS and the DRS

ISSN: 1865-3499