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Table 4 Functional analysis of high glucose-regulated up- or downregulated genes

From: Investigation of the influence of high glucose on molecular and genetic responses: an in vitro study using a human intestine model

Upregulated pathways

p value

Number of genes

Ubiquitin-mediated proteolysis

2.4 × 10−2

7

Protein export

6.9 × 10−3

3

Downregulated pathways

 Glycolysis/gluconeogenesis

3.0 × 10−5

10

 Pentose phosphate

4.3 × 10−3

5

 Fructose and mannose metabolism

1.3 × 10−2

5

  1. Microarray data showed a total of 297 upregulated and 382 downregulated genes in response to high glucose treatment. The high glucose-regulated genes were subjected in DAVID bioinformatics analyze program to describe the functional molecular pathways along with the number of genes in each pathway