From: Validation of biomarkers of food intake—critical assessment of candidate biomarkers
Criterion | Experimental study (compliance biomarker) | Observational study | ||
---|---|---|---|---|
Qualitative | Quantitative | Qualitative | Quantitative | |
1 Plausibility | √ | √ | √ | √ |
2 Dose-response | √ | √ | ||
3a Time-response (single dose) | √ | √ | √ | √ |
3b Time-response (multiple doses) | √ | √ | √ | |
4 Robustness | √ | √ | ||
5 Reliability | √ | √ | √ | √ |
6 Stability | √ | √ | √ | √ |
7 Analytical performance | √ | √ | ||
8 Reproducibility | √ | √ |