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Fig. 1 | Genes & Nutrition

Fig. 1

From: Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines

Fig. 1

Effect of 1,25D on selected serotonin degrading pathway and control mRNAs in a serotonergic neuronal cell line. P values listed at the top of bars represent statistical significance for comparison between 1,25D treatment and ethanol vehicle control group in each and all cases. Statistical analyses were performed using ANOVA with a post hoc adjustment of P values via the Dunnett test that compares every mean to a control mean and takes into account the scatter of all the groups. a Expression of SERT in serotonergic rat raphe RN46A-B14 cells treated with 1,25D. Each mRNA value is the average of nine biological replicates ± std. dev. b Expression of MAO-A in serotonergic rat raphe RN46A-B14 cells treated with 1,25D. Each mRNA value is the average of nine biological replicates ± std. dev. c Expression of MAO-B in serotonergic rat raphe RN46A-B14 cells treated with 1,25D. Each mRNA value is the average of 18 biological replicates ± std. dev. d Expression of Cyp24a1 in serotonergic rat raphe RN46A-B14 cells treated with 1,25D. Each mRNA value is the average of nine biological replicates ± std. dev

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Genes & Nutrition

ISSN: 1865-3499

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