Table 3 Dominant biological processes regulated by algae extracts in the absence of ETEC
Dominant biological processes $ | &C-2 h | C-6 h | H-2 h | H-6 h | S-2 h | S-6 h | AM-6 h | important DEGs* |
|---|---|---|---|---|---|---|---|---|
androgen receptor signalling | x | x | ITGAV, YWHAH, CSNK2B, CTNNB1,ITGB5 | |||||
angiogenesis (blood vessel growth) | x | x | x | x | x | HMOX1, FLT1, THBS1, ITGB3, CCL2, NRP2,ITGA6, ITGAV, PTGS2 | ||
apoptosis (programmed cell-death) | x | x | x | x | SPTLC1, ITGB3, THBS1, DDIT4, YWHAH | |||
cell motility | x | x | x | x | ITGB3, ANXA1, ITGA6, ITGAV, TPM1, TPM4 | |||
cytoskeleton | x | x | x | x | SOS2, PFN2, ARPC1A, ARPC1B, PSEN2, ARPC4, RTN4, ITGB3 | |||
extra cellular matrix structure | x | x | x | x | x | CUL1, YWHAH, BTRC /Collagens (COL), SPARC | ||
glycogenesis/glycan synthesis | x | x | x | MUC13, MUC4, HSPG2, PCK2 | ||||
heat shock (stress) | x | x | DNAJB1, and several heat shock proteins (HSP’s) | |||||
hormone processes (Thyroid) | x | x | IGF1R, ITGB3, ITGAV | |||||
immune modulation | x | x | x | cytokines, TGF, chemokines | ||||
inflammation control | x | x | x | x | x | x | HBEGF, CSF2, CXCL2, IL1A, BIRC3, MMP9, CCL20, LTB, BTRC, HSPB2 | |
neutrophil function (innate immune cells) | x | SOS2, LTBP4, MAPK14, FLT1, IGF1R, PDGFA, ACE, EGFR, DDIT4, FGFR1, TGFA, BMP1, CCL2, RPS6, NRP2 | ||||||
NFKB immune signalling | x | x | x | PTGS2, NFKBIA, CXCL8, TNFAIP3, BTRC | ||||
oxidative stress | x | x | x | x | x | x | HMOX1, NQO1, DNAJB1, HSP1A/B | |
Transforming Growth Factor (TGF) | x | CUL1, THBS1, BTRC, ITGB3 | ||||||
translation (protein synthesis) | x | x | x | x | x | EEF1A1, HSP90B1, DDIT3 | ||
tumour necrosis factor (inflammation) | x | x | x | x | x | JAG1, MAPK14, CSF2, CXCL2,TNFAIP3, BIRC3, CASP10, CCL20, CCL2 | ||
lipid and steriod metabolism | x | x | SREBF2 |