Table 4 Dominant biological processes regulated by algae extracts in the presence of ETEC

androgen receptor signalling

x

ITGAV, YWHAH, CSNK2B, CTNNB1, ITGB5

angiogenesis (blood vessel growth)

x

x

x

x

x

HMOX1, FLT1, THBS1, ITGB3, CCL2, NRP2,ITGA6, ITGAV, PTGS2

antigen recognition

x

x

x

x

x

NFKBIE, CXCL2, BCL10, IL1A, FOS, TNFAIP3, BIRC3, NFKBIA, CXCL8

apoptosis

x

x

x

x

x

x

SPTLC1, ITGB3, THBS1, DDIT4, YWHAH

cell motility

x

x

x

x

x

ITGB3, ANXA1, ITGA6, ITGAV, TPM1, TPM4

cytoskeleton

x

x

SOS2, PFN2, ARPC1A, ARPC1B, PSEN2, ARPC4, RTN4, ITGB3

extra cellular matrix structure

x

x

x

x

x

x

CUL1, YWHAH, BTRC/Collagens (COL), SPARC

glycogenesis/glycan synthesis

x

x

x

MUC13, MUC4, HSPG2, PCK2

hormone processes (Thyroid)

x

IGF1R, ITGB3, ITGAV

immune modulation

x

x

x

x

x

cytokines, TGF, chemokines

inflammation

x

x

x

x

x

HBEGF, CSF2, CXCL2, IL1A, BIRC3, MMP9, CCL20, LTB, BTRC, HSPB2

neutrophil function (innate immune cells)

x

x

SOS2, LTBP4, MAPK14, FLT1, IGF1R, PDGFA, ACE, EGFR, DDIT4, FGFR1, TGFA, BMP1, CCL2, RPS6, NRP2

NFKB immune signalling

x

x

x

PTGS2, NFKBIA, CXCL8, TNFAIP3, BTRC

oxidative stress

x

x

x

x

HMOX1, NQO1, EGLN3

Transforming Growth Factor

x

x

CUL1, THBS1, BTRC, ITGB3

translation (protein synthesis)

x

x

x

x

x

x

x

EEF1A1, HSP90B1, DDIT3

tumour necrosis factor (inflammation)

x

x

x

JAG1, MAPK14, CSF2, CXCL2, TNFAIP3, BIRC3, CASP10, CCL20, CCL2, NFKBIA