Table 6 Secreted immune EPs higher expressed in IPECJ2 cells upon exposure to micro algae extracts alone and mixtures of extracts and ETEC
#DEG | Full Name | function | association with chemicals produced by microalgae |
|---|---|---|---|
CCL17 | C-C Motif Chemokine Ligand 17 | T cell development in thymus and attraction and activation of mature T cells. | carotenoids / flavonoids |
CXCL2 | C-X-C Motif Chemokine Ligand 2 | leukocyte recruitment (including T-cells) | carotenoids / flavonoids /endotoxins / sulphated polysaccharides (Carrageenan) |
CXCL8 | C-X-C Motif Chemokine Ligand 8 | major mediator inflammatory response / attraction and activation neutrophils and macrophages | Fatty Acids, Omega-3 / carotenoids / flavonoids / Phytosterols (e.g. coagulin-L) / sulphated polysaccharides (Carrageenan) |
IFNA1 | Interferon Alpha 1 | cytokine mediating an antiviral state | micro algae lectins |
IFNL1 | Interferon Lambda 1 | cytokine mediating an antiviral state | flavonoids |
HMOX1 | Heme Oxygenase 1 | protection against oxidative stress (breakdown of apoptosis-inducing free heme) / blood vessel widening (vasodilation). | Fatty Acids, Omega-3 / carotenoids (astaxanthine) / flavonoids / Phytosterols (e.g. coagulin-L) / sulphated polysaccharides (e.g. fucoidan) |
ITGB3 | Integrin Subunit Beta 3 receptor | thrombospondin and metallo-protease mediated ECM remodelling and focal adhesion (e.g. in the process of trans-endothelial migration of leukocytes) | flavonoids |
THBS1 | Thrombospondin 1 | glycoprotein mediating cell-to-cell and cell-to-matrix interactions /anti-angiogenic properties/ fibrotic response in inflammation | Fatty Acids, Omega-3 / carotenoids / flavonoids / Phytosterols / sulphated polysaccharides |