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Table 4 Association between dietary GI change across gestation and placental methylation levels of CpG sites based on stepwise regression analysis

From: Maternal dietary glycaemic change during gestation influences insulin-related gene methylation in the placental tissue: a genome-wide methylation analysis

Dependent variables

Fmodel

Pmodel

Adjusted Model R2, %

Dietary GI change

Significant covariates

P

β(95%CI)

EV,%

cg17586860

4.33

0.007

9.3

0.003

-0.36

72.8%

GDM, GI-baseline

cg20950011

3.04

0.053

4.0

>0.05

-

-

GDM, BMI

  1. Only significant models were presented. Maternal age, BMI, HOMA-IR and dietary GI at baseline, GDM, gestational age at delivery and gestational weight gain were adjusted as covariates
  2. EV explained variation