Weighted gene co-expression network analysis to explain the relationship between plasma total carotenoids and lipid profile

Table 2 Hub genes identified in the brown module

Probe ID	Gene (Chr, accession number)	GS HDL-C	p value GS	MM	p value MM	Potential causal relationships of the hub genes¹
ID_4920064	CISH (Chr3, NM_145071)	0.29	0.049	0.67	1.44 × 10⁻⁷	Likely regulator
ID_6480731	AMER3 (Chr2, NM_ 001105193)	0.36	0.011	0.68	1.12 × 10⁻⁷	Likely regulated
ID_3870603	ZSWIM4 (Chr19, NM_ 023072)	0.29	0.047	0.69	5.12 × 10⁻⁸	Unknown
ID_290093	LOC647322 (Chr2, withdrawn)	0.32	0.028	0.74	2.39 × 10⁻⁹	Unknown
ID_4540376	FAM13A (Chr4, NM_ 001015045)	0.29	0.047	0.76	2.88 × 10⁻¹⁰	Likely regulator
ID_2260315	HS.572752	0.29	0.047	0.77	1.48 × 10⁻¹⁰	Unknown
ID_3420706	HS.566359	0.29	0.049	0.83	2.03 × 10⁻¹³	Unknown

Chr chromosome, GS gene significance, HDL-C high-density lipoprotein cholesterol, MM module membership
¹Classification terms have been added to suggest potential causal relationships of the hub genes in the interconnection between total carotenoids and plasma lipid concentrations