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Table 5 Correlations between intake levels of protein from different sources and fold change expression of RhoA, VEGF-A, and VEGFR2 within each category of ALNM status

From: Dietary protein sources and tumoral overexpression of RhoA, VEGF-A and VEGFR2 genes among breast cancer patients

Dietary variables Fold change of RhoA Fold change of VEGF-A Fold change of VEGFR2
ALNM+ (n = 92) ALNM− (n = 53) ALNM+ (n = 87) ALNM− (n = 52) ALNM+ (n = 87) ALNM− (n = 46)
β § p value β adj. ¥ p value β p value β adj. p value β p value β adj. p value β p value β adj. p value β p value β adj. p value β p value β adj. p value
Total protein* 0.104 0.346 0.216a 0.079 − 0.03 0.819 − 0.177 0.291 0.013 0.908 0.088n 0.477 0.321 0.017 0.339 0.019 0.257 0.015 0.295 aa 0.009 0.095 0.503 0.050 0.747
Animal protein* 0.158 0.154 0.238 b 0.041 − 0.050 0.708 0.205 0.217 0.117 0.283 0.099o 0.382 0.117 0.400 0.107 0.461 − 0.060 0.580 − 0.059bb 0.593 0.428 0.002 0.446 0.002
Plant protein* − 0.009 0.936 − 0.195c 0.168 0.062 0.635 − 0.181 0.301 0.090 0.408 0.091p 0.425 0.187 0.169 0.176 0.257 − 0.112 0.303 − 0.116cc 0.316 0.146 0.305 0.137 0.354
Red meat 0.182 0.085 0.230 d 0.039 − 0.027 0.841 0.073 0.632 0.294 0.005 0.321 q 0.003 0.197 0.143 0.221 0.115 − 0.078 0.460 − 0.013dd 0.909 0.425 0.002 0.444 0.002
Processed red meat 0.067 0.533 0.102e 0.374 − 0.005 0.973 0.006 0.967 0.058 0.577 0.047r 0.695 0.117 0.386 0.082 0.617 0.152 0.151 0.265 ee 0.030 0.066 0.641 0.202 0.186
Poultries − 0.135 0.226 − 0.163f 0.185 − 0.089 0.543 − 0.139 0.372 − 0.018 0.862 − 0.039s 0.744 − 0.092 0.503 − 0.136 0.396 − 0.031 0.772 − 0.066ff 0.569 0.042 0.781 0.043 0.805
Seafood − 0.034 0.747 − 0.083g 0.493 − 0.109 0.444 − 0.086 0.643 0.040 0.727 0.086t 0.496 0.124 0.396 0.141 0.380 − 0.055 0.600 − 0.013gg 0.911 0.140 0.322 0.101 0.520
Dairy products 0.132 0.215 0.271 h 0.03 − 0.035 0.806 0.024 0.889 0.157 0.132 0.203u 0.067 0.094 0.487 0.106 0.501 0.067 0.524 0.125hh 0.285 0.017 0.908 0.458 0.003
Legumes 0.021 0.841 0.005i 0.964 − 0.011 0.940 0.015 0.928 0.237 0.025 0.205v 0.095 − 0.196 0.145 − 0.267 0.147 − 0.154 0.155 − 0.201ii 0.089 − 0.007 0.959 − 0.095 0.560
Nuts and cereals − 0.130 0.226 − 0.239 j 0.043 − 0.021 0.879 − 0.099 0.543 0.072 0.492 0.064w 0.574 0.080 0.547 − 0.019 0.912 0.020 0.193 0.091jj 0.413 − 0.169 0.227 − 0.219 0.153
Residual protein 0.128 0.250 0.228k 0.086 − 0.158 0.268 − 0.207 0.228 0.071 0.544 0.142x 0.249 0.258 0.080 0.272 0.107 0.077 0.493 0.184kk 0.121 − 0.058 0.709 0.123 0.491
Total protein/dietary fiber 0.177 0.102 0.242 l 0.040 − 0.033 0.802 0.119 0.488 0.006 0.954 − 0.055y 0.643 0.089 0.514 0.064 0.649 0.002 0.988 0.129ll 0.301 0.158 0.264 0.303 0.041
Animal protein/plant protein 0.173 0.111 0.273 m 0.022 − 0.029 0.853 0.002 0.993 − 0.017 0.871 − 0.032z 0.791 − 0.020 0.892 0.112 0.507 0.081 0.451 − 0.031mm 0.787 0.300 0.038 0.388 0.011
  1. ALNM axillary lymph node metastasis
  2. *Energy-adjusted variables in terms of nutrient density was estimated. §Values are expressed as β from simple linear regression model. ¥Values are expressed as β from multivariate linear regression adjusted model. Dietary variables adjusted for the following: aMean duration of breastfeeding (months), BMI (kg/m2), OCP usage, and menopause status. bCrude fiber (g/day) and age of first childbirth (years). cEnergy intake (kcal/day), dietary fiber (g/day), the age of menarche (years), menopause status, and BMI (kg/m2). dEnergy intake (kcal/day). eEnergy intake (kcal/day) and tumor size (cm). fLog transformed and adjusted for fat intake (g/day), the age of menarche (years), and tumor size. gAge of first childbirth (years), the age of menarche (years), and waist circumference (cm). hLog transformed and adjusted for energy intake (kcal/day), BMI (kg/m2), the age of first childbirth (years), and mean duration of breastfeeding (months). iBMI (kg/m2), tumor size (cm), and carbohydrate intake (g/day). jLog transformed and adjusted for fat intake (g/day), the mean duration of breastfeeding (months), dietary fiber (g/day), and BMI (kg/m2). kMean duration of breastfeeding (months), BMI (kg/m2), fat intake(g/day), and soluble fiber (g/day). lCarbohydrate intake (g/day), the age of menarche (years), and mean duration of breastfeeding (months). mFat intake (g/day), the age of first childbirth (years), and number of lactation (n). nFat intake (g/day), tumor size (cm), and carbohydrate intake (g/day). oFat intake (g/day) and tumor size (cm). pDietary fiber intake (g/day) and waist to hip ratio. qFat intake (g/day). rFat intake (g/day), red meat intake (g/day), the age of first childbirth (years), waist to hip ratio, and age of menarche (years). sFat intake (g/day), mean duration of breastfeeding (months), and BMI (kg/m2). tLog transformed and adjusted for energy intake (kcal/day) and mean duration of breastfeeding (months). uFat intake (g/day), red meat intake (g/day), number of pregnancies (n), and physical activity rate. vLog transformed and adjusted for energy intake (kcal/day), insoluble fiber intake (g/day), and age at diagnosis (years). wEnergy intake (kcal/day), insoluble fiber (g/day), and waist to hip ratio. xFat intake (g/day), BMI (kg/m2), and tumor size (cm). yFat intake (g/day) and tumor size (cm). zFat intake (g/day), the age of first childbirth (years), and waist to hip ratio. aaDietary fiber intake (g/day), fat intake (g/day), and tumor size (cm). bbMean duration of breastfeeding (months) and tumor size (cm). ccFat intake (g/day) and age of menarche (years). ddFat intake (g/day), BMI (kg/m2), and tumor size (cm). eeRed meat intake (g/day), fat intake (g/day), and tumor size (cm). ffFat intake (g/day), soluble fiber (g/day), and waist to hip ratio. ggEnergy intake (kcal), mean duration of breastfeeding (months), and tumor size (cm). hhRed meat intake (g/day), mean duration of breastfeeding (months), physical activity rate, and tumor size (cm). iiLog transformed and adjusted for fat intake (g/day), waist to hip ratio, and tumor size (cm). jjLog transformed and adjusted waist circumference (cm). kkFat intake (g/day), tumor size (cm), and waist circumference (cm). llCarbohydrate intake (g/day), the age of menarche (years), and waist to hip ratio. mmFat intake (g/day) and BMI (kg/m2)