Evidence for the association between FTO gene variants and vitamin B12 concentrations in an Asian Indian population

Table 2 Association between the FTO-GRS with vitamin B12, folic acid, homocysteine, and obesity traits

Risk alleles	n	Vitamin B12 (pg/mL)	n	Homocysteine (μmol/L)	n	Folic acid (ng/ml)	n	BMI (kg/m²)	n	WC (cm)	n	Odds Ratio (95% CI) of Obesity
0	380	410 ± 202	390	13.2 ± 7.7	390	8.89 ± 5.92	390	26.4 ± 5.0	390	87.6 ± 11.1	194	1.63 (1.07-2.49)
≥ 1	154	356 ± 189	157	14.8 ± 8.9	157	7.89 ± 5.48	157	27.6 ± 5.0	156	90.0 ± 11.6	353	1.63 (1.07-2.49)
P value	0.018		0.077		0.147		0.009†		0.747		*0.023

Values are given as mean ± standard deviation
P values for differences between 0 and 1 risk alleles were obtained using linear regression model adjusted age, BMI, type 2 diabetes status, type 2 diabetes medication, and sex
†P values were obtained by using a general linear model adjusted for age, type 2 diabetes status, type 2 diabetes medication, and sex
*P values were adjusted for age, sex, and type 2 diabetes status using binary logistic regression
Abbreviations: BMI body mass index; WC waist circumference; WHR waist to hip ratio

ISSN: 1865-3499