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Table 3 Genes significantly regulated after intake of protein (FDR, q < 0.25)

From: Increased protein intake affects pro-opiomelanocortin (POMC) processing, immune function and IGF signaling in peripheral blood mononuclear cells of home-dwelling old subjects using a genome-wide gene expression approach

Gene symbol

Name

Biological processa

Log FC

p value

FDR

ZNF683

Zinc Finger Protein 683

Adaptive and innate immune response in NK-cells, transcription

0.367

6.75E-05

0.112

ZNF543

Zinc finger protein 543

Transcription

0.362

1.17E-07

0.001

MICA/B

MHC Class I Polypeptide-Related Sequence A/B

Immune response, T-cell mediated cytotoxicity

0.324

3.68E-05

0.074

KIR2DL1

Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 1

Natural killer cell inhibitory signaling pathway

0.321

7.80E-05

0.112

CCL4L2

C-C Motif Chemokine Ligand 4 Like 2

Inflammatory response

0.315

1.01E-04

0.117

KIR2DL4

Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 4

Immune response

0.296

3.51E-04

0.228

FGFBP2

Fibroblast Growth Factor Binding Protein 2

Growth factor binding

0.294

2.29E-04

0.214

HOPX

HOP homeobox

Transcription

0.289

2.93E-05

0.073

MMP23B

Matrix Metallopeptidase 23B

Proteolysis and reproduction

0.287

3.71E-04

0.228

ADGRG1

Adhesion G Protein-Coupled Receptor G1

Cell adhesion and migration, cell proliferation, signal transduction

0.273

3.47E-04

0.228

KLRC3

Killer Cell Lectin Like Receptor C3

Cellular defense response

0.270

8.28E-05

0.112

CLIC3

Chloride Intracellular Channel 3

Regulation of ion transmembrane transport

0.265

5.08E-04

0.228

PRSS30P

Protease, Serine, 30 Pseudogene

Pseudogene

0.261

1.10E-04

0.117

NMUR1

Neuromedin U Receptor 1

Calcium-mediated signaling, chloride transport, G-protein coupled receptor signaling pathway

0.258

4.99E-04

0.228

PTGDR

Prostaglandin D2 Receptor

G-protein coupled receptor signaling pathway, cellular and inflammatory responses

0.249

4.48E-04

0.228

KIR3DL3

Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3

Immune response

0.243

4.20E-04

0.228

GNLY

Granulysin

Antimicrobial humoral immune response mediated by antimicrobial peptide

0.237

3.02E-05

0.073

PRL23A

Ribosomal protein L23a

Cell proliferation

0.222

8.73E-06

0.035

KIR-K36

Killer Cell Immunoglobulin Like Receptor – K36

Defense response

0.222

1.16E-04

0.117

CTSW

Cathepsin W

Immune response

0.221

4.71E-04

0.228

KIR2DS5

Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 5

Immune response

0.211

4.68E-04

0.228

HERC3

HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 3

Protein ubiquitination

0.165

4.85E-04

0.228

CCDC65

Coiled-Coil Domain Containing 65

The protein plays a critical role in the assembly of the nexin-dynein regulatory complex.

0.159

4.40E-04

0.228

ABHD17A

Abhydrolase Domain Containing 17A

Protein palmitoylation

0.156

3.06E-04

0.228

TMEM87B

Transmembrane Protein 87B

Involved in endosome-to-trans-Golgi network retrograde transport.

0.139

2.6E-04

0.228

TLR9

Toll Like Receptor 9

Immune response

-0,199

4.51E-04

0.228

KDM5A

Lysine-specific demethylase 5A

Regulation of histone deacetylase activity, transcription

-0,282

4.59E-07

0.003

  1. aBiological process as defined by UniProtKB (https://www.uniprot.org/). log FC; log fold change, FDR; false discovery rate