Increased protein intake affects pro-opiomelanocortin (POMC) processing, immune function and IGF signaling in peripheral blood mononuclear cells of home-dwelling old subjects using a genome-wide gene expression approach

Table 4 Genes significantly regulated after intake of carbohydrates (FDR, q < 0.25)

Gene symbol	Name	Biological process^a	Log FC	p value	FDR
MICA/B	MHC Class I Polypeptide-Related Sequence A/B	Immune response, T-cell mediated cytotoxicity	0.410	8.5E-10	5.82E-06
ZNF543	Zinc finger protein 543	Transcription	0.301	1.22E-06	0.003
PRL23A	Ribosomal protein L23a	Cell proliferation	0.260	2.04E-07	0.0006
ANO8	Anoctamin 8	Chloride transport	0.198	5.61E-05	0.114
KDM5A	Lysine-specific demethylase 5A	Regulation of histone deacetylase activity, transcription	-0,424	9.58E-10	5.82E-06
HBG2	Hemoglobin Subunit Gamma 2	Blood coagulation	-0,434	7.92E-05	0.137
S1PR5	Sphingosine-1-Phosphate Receptor 5	G-protein coupled receptor signaling pathway	-0,597	2.51E-08	0.0001

^aBiological process as defined by UniProtKB (https://www.uniprot.org/). log FC; log fold change, FDR; false discovery rate

ISSN: 1865-3499